Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we...

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Bibliographic Details
Published in:BMC medical genetics 2018-03, Vol.19 (1), p.38-38, Article 38
Main Authors: Ding, Weiyue, Xu, Li, Zhang, Lejun, Han, Zhijie, Jiang, Qinghua, Wang, Zhe, Jin, Shuilin
Format: Article
Language:English
Subjects:
Alleles
Asian People - genetics
Cellular signal transduction
Databases, Factual
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - genetics
Gene expression
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Humans
Meta-analysis
Polymorphism
Polymorphism, Single Nucleotide
Publication Bias
Risk factors
rs7903146
T2DM
Transcription Factor 7-Like 2 Protein - genetics
Transcription factors
Type 2 diabetes
White People - genetics
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Summary:Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result. The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta. The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p 
ISSN:1471-2350
1471-2350
DOI:10.1186/s12881-018-0553-5