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Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus
Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we...
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| Published in: | BMC medical genetics 2018-03, Vol.19 (1), p.38-38, Article 38 |
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| creator | Ding, Weiyue Xu, Li Zhang, Lejun Han, Zhijie Jiang, Qinghua Wang, Zhe Jin, Shuilin |
| description | Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result.
The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta.
The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p |
| doi_str_mv | 10.1186/s12881-018-0553-5 |
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The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta.
The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, p < 0.0001).
The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.</description><identifier>ISSN: 1471-2350</identifier><identifier>EISSN: 1471-2350</identifier><identifier>DOI: 10.1186/s12881-018-0553-5</identifier><identifier>PMID: 29514658</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Alleles ; Asian People - genetics ; Cellular signal transduction ; Databases, Factual ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - genetics ; Gene expression ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Humans ; Meta-analysis ; Polymorphism ; Polymorphism, Single Nucleotide ; Publication Bias ; Risk factors ; rs7903146 ; T2DM ; Transcription Factor 7-Like 2 Protein - genetics ; Transcription factors ; Type 2 diabetes ; White People - genetics</subject><ispartof>BMC medical genetics, 2018-03, Vol.19 (1), p.38-38, Article 38</ispartof><rights>COPYRIGHT 2018 BioMed Central Ltd.</rights><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-a269f434cf8788acd50762d90c81f4082744793815566e48923ad51f774b42f43</citedby><cites>FETCH-LOGICAL-c566t-a269f434cf8788acd50762d90c81f4082744793815566e48923ad51f774b42f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842570/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842570/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,37012,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29514658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Weiyue</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Zhang, Lejun</creatorcontrib><creatorcontrib>Han, Zhijie</creatorcontrib><creatorcontrib>Jiang, Qinghua</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Jin, Shuilin</creatorcontrib><title>Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus</title><title>BMC medical genetics</title><addtitle>BMC Med Genet</addtitle><description>Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result.
The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta.
The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, p < 0.0001).
The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.</description><subject>Alleles</subject><subject>Asian People - genetics</subject><subject>Cellular signal transduction</subject><subject>Databases, Factual</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Publication Bias</subject><subject>Risk factors</subject><subject>rs7903146</subject><subject>T2DM</subject><subject>Transcription Factor 7-Like 2 Protein - genetics</subject><subject>Transcription factors</subject><subject>Type 2 diabetes</subject><subject>White People - genetics</subject><issn>1471-2350</issn><issn>1471-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkkuLFDEUhQtRnLH1B7iRgBtd1Jhn5WYjDI2jDS2CjuuQzqMnQ1WlraTV_vem7HGYBski4eacj3uT0zQvCb4gBLp3mVAA0mICLRaCteJRc064JC1lAj9-cD5rnuV8izGRwNjT5owqQXgn4LzRn30xrRlNf8gxoxSQyTnZaEpMI9r48sv7EV0vr-Saol3qD0OadjcxD2jKUmFWMciMDpXDziOKXDTV4zMafN_Hss_PmyfB9Nm_uNsXzferD9fLT-36y8fV8nLdWtF1pTW0U4EzbgNIAGOdwLKjTmELJHAMVHIuFQMiqtxzUJQZJ0iQkm84rc5FszpyXTK3ejfFwUwHnUzUfwtp2mozlWh7r5XoQKkN2A4spxQUgHMsgAvAneIz6_2RtdtvBu-sH8tk-hPo6c0Yb_Q2_dQCOBUSV8CbO8CUfux9LnqI2dYXMaNP-6wpJnT-wDrRonl9lG5NbS2OIVWineX6UnCJhSQdq6qL_6jqcn6INo0-xFo_Mbw9MVRN8b_L1uxz1qtvX0-15Ki1U8p58uF-UoL13KY-5kzXnOk5Z1pUz6uHT3Tv-Bcs9gdWfslo</recordid><startdate>20180307</startdate><enddate>20180307</enddate><creator>Ding, Weiyue</creator><creator>Xu, Li</creator><creator>Zhang, Lejun</creator><creator>Han, Zhijie</creator><creator>Jiang, Qinghua</creator><creator>Wang, Zhe</creator><creator>Jin, Shuilin</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180307</creationdate><title>Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus</title><author>Ding, Weiyue ; Xu, Li ; Zhang, Lejun ; Han, Zhijie ; Jiang, Qinghua ; Wang, Zhe ; Jin, Shuilin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-a269f434cf8788acd50762d90c81f4082744793815566e48923ad51f774b42f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alleles</topic><topic>Asian People - genetics</topic><topic>Cellular signal transduction</topic><topic>Databases, Factual</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Publication Bias</topic><topic>Risk factors</topic><topic>rs7903146</topic><topic>T2DM</topic><topic>Transcription Factor 7-Like 2 Protein - genetics</topic><topic>Transcription factors</topic><topic>Type 2 diabetes</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Weiyue</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Zhang, Lejun</creatorcontrib><creatorcontrib>Han, Zhijie</creatorcontrib><creatorcontrib>Jiang, Qinghua</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Jin, Shuilin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>BMC medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Weiyue</au><au>Xu, Li</au><au>Zhang, Lejun</au><au>Han, Zhijie</au><au>Jiang, Qinghua</au><au>Wang, Zhe</au><au>Jin, Shuilin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus</atitle><jtitle>BMC medical genetics</jtitle><addtitle>BMC Med Genet</addtitle><date>2018-03-07</date><risdate>2018</risdate><volume>19</volume><issue>1</issue><spage>38</spage><epage>38</epage><pages>38-38</pages><artnum>38</artnum><issn>1471-2350</issn><eissn>1471-2350</eissn><abstract>Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result.
The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta.
The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, p < 0.0001).
The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>29514658</pmid><doi>10.1186/s12881-018-0553-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central; Publicly Available Content Database |
| subjects | Alleles Asian People - genetics Cellular signal transduction Databases, Factual Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - genetics Gene expression Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Humans Meta-analysis Polymorphism Polymorphism, Single Nucleotide Publication Bias Risk factors rs7903146 T2DM Transcription Factor 7-Like 2 Protein - genetics Transcription factors Type 2 diabetes White People - genetics |
| title | Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus |
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