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Assessment of Zinc-Bound Phosphate-Based Glass-Coated Denture-Relining Material with Antifungal Efficacy for Inhibiting Denture Stomatitis

This study investigated the surface properties, biocompatibility, and antifungal activity against Candida albicans of a denture-relining material coated with zinc-bound phosphate-based glass. First, zinc-bound phosphate-based glass was fabricated. A polymerized denture-relining disk was coated with...

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Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2022-09, Vol.12 (17), p.3048
Main Authors: Oh, Sang-Hwan, Jung, Yun-Sook, Lee, Myung-Jin
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description This study investigated the surface properties, biocompatibility, and antifungal activity against Candida albicans of a denture-relining material coated with zinc-bound phosphate-based glass. First, zinc-bound phosphate-based glass was fabricated. A polymerized denture-relining disk was coated with zinc-bound phosphate-based glass (2%, 4%, and 6%). The surface properties of the control and experimental groups were measured, including the wettability, microhardness, color difference, and gloss. The biocompatibility was evaluated using the MTT assay according to ISO 10993-5. The antifungal activity was investigated by counting the number of colony-forming units of Candida albicans. The results were analyzed using a one-way ANOVA and Tukey’s test (p = 0.05). The results of this study indicate that, despite the antimicrobial effect of zinc-bound phosphate-based glass, a coated denture-relining material does not degrade the surface properties and biocompatibility. Therefore, this novel material is considered promising for use as a dental material with antimicrobial properties that can potentially prevent denture stomatitis.
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First, zinc-bound phosphate-based glass was fabricated. A polymerized denture-relining disk was coated with zinc-bound phosphate-based glass (2%, 4%, and 6%). The surface properties of the control and experimental groups were measured, including the wettability, microhardness, color difference, and gloss. The biocompatibility was evaluated using the MTT assay according to ISO 10993-5. The antifungal activity was investigated by counting the number of colony-forming units of Candida albicans. The results were analyzed using a one-way ANOVA and Tukey’s test (p = 0.05). The results of this study indicate that, despite the antimicrobial effect of zinc-bound phosphate-based glass, a coated denture-relining material does not degrade the surface properties and biocompatibility. 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subjects Antifungal activity
antifungal efficacy
Antiinfectives and antibacterials
Antimicrobial agents
Biocompatibility
Candida albicans
Coatings
Composite materials
Contact angle
Cytotoxicity
Dental materials
Dentistry
Dentures
Disinfection & disinfectants
Drug resistance
Fungicides
Glass
Gloss
Identification and classification
Lining processes
Medical technology
Microhardness
Mold
Older people
Phosphate
Phosphates
Population
Prevention
Properties
Prostheses
Scanning electron microscopy
Stomatitis
surface characterization
Surface properties
Variance analysis
Wettability
Zinc
Zinc coatings
Zinc compounds
zinc-bound phosphate-based glass
title Assessment of Zinc-Bound Phosphate-Based Glass-Coated Denture-Relining Material with Antifungal Efficacy for Inhibiting Denture Stomatitis
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