Licochalcone A in Combination with Salicylic Acid as Fluid Based and Hydroxy-Complex 10% Cream for the Treatment of Mild Acne: A Multicenter Prospective Trial

Topical cosmetic agents if correctly prescribed and used may improve outcomes in acne therapy. The aim of this study was to assess the efficacy and tolerability of a new daily cosmetic regimen in the treatment of mild facial acne. A multicenter, prospective, observational, clinical study was conduct...

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Bibliographic Details
Published in:Clinical, cosmetic and investigational dermatology cosmetic and investigational dermatology, 2020-01, Vol.12, p.961-967
Main Authors: Dall'Oglio, Federica, Fabbrocini, Gabriella, Tedeschi, Aurora, Donnarumma, Marianna, Chiodini, Paolo, Micali, Giuseppe
Format: Article
Language:English
Subjects:
Acne
Antiacne agents
Antibiotics
Carnitine
Clinical trials
Dermatologic agents
Digital photography
Drug therapy
Hydroxides
hydroxyl-complex
licochalcone a
Medical research
mild acne
Original Research
Patients
Phenols (Class of compounds)
salycilic acid
Skin
topical cosmetic
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Summary:Topical cosmetic agents if correctly prescribed and used may improve outcomes in acne therapy. The aim of this study was to assess the efficacy and tolerability of a new daily cosmetic regimen in the treatment of mild facial acne. A multicenter, prospective, observational, clinical study was conducted on 91 adult patients with mild acne. Subjects were instructed to apply a fluid containing Licochalcone A/Salicylic acid/L-Carnitine in the morning and a cream with Licochalcone A/Hydroxy-Complex 10% at bedtime for 8 weeks. The efficacy was clinically evaluated by Global Acne Grading System (GAGS) score and by comedones/papules lesions count and by instrumental assessment (Sebutape and Reveal Photo Imager/VISIA-CR™ imaging) at baseline, at 4 and 8 weeks. At 4 weeks a statistically significant reduction from baseline of GAGSwas observed. In addition, the mean total count of comedones and papules was significantly reduced by 41% and 45%, respectively, from baseline along with a significant reduction of mean sebum of 47%. At 8 weeks, a further statistically significant reduction from baseline of GAGS, total count of comedones and papules (64% and 71%, respectively), along with an additional sebum reduction of about 52% was also recorded. Our results suggest that the daily regimen based on Licochalcone A with Salicylic acid/L-Carnitine as fluid or with Hydroxy-Complex 10% as cream represent an interesting cosmetic approach for treating mild acne.
ISSN:1178-7015
1178-7015
DOI:10.2147/CCID.S206935