Thermal Analysis Study of Antihypertensive Drugs Telmisartan and Cilazapril

Purpose: The aim of the present work is to study the thermal analysis of telmisartan and cilazapril. Methods: Thermogravimetry (TGA), derivative thermogravimetry (DTG) and differential thermal analysis (DTA) were used through the work to achieve the thermal analysis study of some antihypertensive dr...

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Bibliographic Details
Published in:Advanced pharmaceutical bulletin 2014, Vol.4 (3), p.283-287
Main Authors: Saber, Refaat Ahmed, Attia, Ali Kamal, Salem, Waheed Mohamed
Format: Article
Language:English
Subjects:
Antihypertensive
Cilazapril
Drugs
Quality control
Telmisartan
Thermal analysis
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Summary:Purpose: The aim of the present work is to study the thermal analysis of telmisartan and cilazapril. Methods: Thermogravimetry (TGA), derivative thermogravimetry (DTG) and differential thermal analysis (DTA) were used through the work to achieve the thermal analysis study of some antihypertensive drugs, telmisartan and cilazapril. Results: The results led to thermal stability data and also to the interpretation concerning the thermal decomposition. Thermogravimetry data allowed determination of the kinetic parameters such as, activation energy and frequency factor. Conclusion: The simplicity, speed and low operational costs of thermal analysis justify its application in the quality control of pharmaceutical compounds for medications.
ISSN:2228-5881
2251-7308
DOI:10.5681/apb.2014.041