Prevalence of the CYP2D610 (C100T), 4 (G1846A), and 14 (G1758A) alleles among Iranians of different ethnicities

The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. Here, we compared the prevalence of the CYP2D6*10, *4, and 14* alleles in an Iranian population of different ethnicities with those of other p...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2015-05, Vol.9 (default), p.2627-2634
Main Authors: Bagheri, Ali, Kamalidehghan, Behnam, Haghshenas, Maryam, Azadfar, Parisa, Akbari, Leila, Sangtarash, Mohammad Hossein, Vejdandoust, Faramarz, Ahmadipour, Fatemeh, Meng, Goh Yong, Houshmand, Massoud
Format: Article
Language:English
Subjects:
Adult
Alleles
Amino Acid Sequence
Animals
antidepressants
antipsychotics
Base Sequence
CYP
Cytochrome P-450 CYP2D6 - genetics
cytochrome P450 genes
DNA - genetics
Ethnic Groups - statistics & numerical data
Female
Gene Frequency
Humans
Iran - epidemiology
Iranian population
Male
Molecular Sequence Data
Original Research
pharmacogenetics
Phenotype
polymorphism
Polymorphism, Restriction Fragment Length - genetics
Prevalence
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Summary:The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. Here, we compared the prevalence of the CYP2D6*10, *4, and 14* alleles in an Iranian population of different ethnicities with those of other populations. Allele and genotype frequency distributions of CYP2D6*10 variants and predicted phenotypes including extensive metabolizers, intermediate metabolizers, and poor metabolizers were analysed in blood samples of 300 unrelated healthy individuals in an Iranian population using polymerase chain reaction (PCR)-restriction fragment length polymorphism, PCR-single-strand conformation polymorphism, and direct genomic DNA sequencing. The CYP2D6*4 (G1846A) and *14 (G1758A) allelic frequencies were not detected in different ethnicities, demonstrating the absence of a significant contribution of these alleles in Iranian populations. However, the T/T, C/T, and C/C genotype frequencies of the CYP2D6*10 allele were significantly different (P
ISSN:1177-8881
1177-8881
DOI:10.2147/dddt.s79709