Evaluation of micronuclei and antioxidant status in hospital radiation workers occupationally exposed to low-dose ionizing radiation

There is scientific evidence that ionizing radiation (IR) can be responsible for various health hazards that are one of the concerns in occupational exposure. This study was performed to evaluate DNA damage and antioxidant status in hospital workers who are occupationally exposed to low doses of IR....

Full description

Saved in:
Bibliographic Details
Published in:BMC health services research 2023-05, Vol.23 (1), p.540-540, Article 540
Main Authors: Mousavikia, S N, Bahreyni Toossi, M T, Khademi, S, Soukhtanloo, M, Azimian, H
Format: Article
Language:English
Subjects:
Adaptive-response
Antioxidants
Cell cycle
DNA damage
Free radicals
Health services
Hospitals
Humans
Ionizing radiation
Lymphocytes
Micronuclei
Normal distribution
Oxidative stress
Personnel, Hospital
Radiation
Radiation, Ionizing
Statistical analysis
Superoxide Dismutase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is scientific evidence that ionizing radiation (IR) can be responsible for various health hazards that are one of the concerns in occupational exposure. This study was performed to evaluate DNA damage and antioxidant status in hospital workers who are occupationally exposed to low doses of IR. In this study, twenty occupationally exposed to low doses of IR (CT and angiography) comprising with control groups which matched them. In order to investigate the effects of chronic irradiation of radiation workers, Micronuclei (MN) frequency and the antioxidant activity of Superoxide Dismutase (SOD), Catalase (CAT) and Total Antioxidant Capacity (TAC) were measured. Then, to check adaptation against high challenge dose, the samples (in all groups) were irradiated in vitro and MN frequency was compared. Finally, to investigated the effect of the high dose after the acute and chronic low dose of ionizing radiation, MN frequency was compared in two groups (the control group that was to in-vitro irradiated (acute low dose + high dose) and radiation workers (chronic low dose + high dose)). MN frequency in the occupationally exposed group (n = 30) increased significantly when compared to the control group (p-value  0.05). We observed that exposure to low doses of IR leads to increased cytogenetic damage, could not cause an adaptive-response, and improve antioxidant capacity in radiation workers. Controlling healthcare workers' exposure is the first step to improving the health of hospital workers and the quality of patient care, thus decreasing human and economic costs.
ISSN:1472-6963
1472-6963
DOI:10.1186/s12913-023-09516-2