Biochemical markers of bone collagen type I metabolism

This review focuses on the analysis of diagnostic value of the major bone remodeling markers, in particular synthesis and degradation markers of collagen type I. These include carboxy- and aminoterminal telopeptide, carboxy- and aminoterminal propeptide of procollagen type I, hydroxyproline, hydroxy...

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Bibliographic Details
Published in:Ukrainian biochemical journal 2015, Vol.87 (1), p.21-32
Main Authors: Zaitseva, O V, Shandrenko, S G, Veliky, M M
Format: Article
Language:English
Subjects:
Acid Phosphatase - metabolism
Alkaline Phosphatase - metabolism
Amino Acids - blood
Amino Acids - urine
Animals
Biomarkers - blood
Biomarkers - urine
Bone and Bones - metabolism
Bone and Bones - pathology
Bone Density
Bone Resorption - blood
Bone Resorption - pathology
Bone Resorption - urine
Collagen Type I - metabolism
Humans
Hydroxylysine - blood
Hydroxylysine - urine
Hydroxyproline - blood
Hydroxyproline - urine
Osteocalcin - metabolism
Peptide Fragments - blood
Peptide Fragments - urine
Procollagen - metabolism
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Summary:This review focuses on the analysis of diagnostic value of the major bone remodeling markers, in particular synthesis and degradation markers of collagen type I. These include carboxy- and aminoterminal telopeptide, carboxy- and aminoterminal propeptide of procollagen type I, hydroxyproline, hydroxylysine, pyridinoline and deoxypyridinoline. Their measurement allows evaluating the structural and functional conditions and also the rate of metabolic processes in the bone tissue. The advantages and disadvantages of determination of these markers in the condition of different bone diseases were examined. It is shown that determination of bone collagen type I metabolism markers is the most informative for assessment of bone resorption, formation and turnover.
ISSN:2409-4943
2413-5003
DOI:10.15407/ubj87.01.021