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Biochemical markers of bone collagen type I metabolism
This review focuses on the analysis of diagnostic value of the major bone remodeling markers, in particular synthesis and degradation markers of collagen type I. These include carboxy- and aminoterminal telopeptide, carboxy- and aminoterminal propeptide of procollagen type I, hydroxyproline, hydroxy...
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Published in: | Ukrainian biochemical journal 2015, Vol.87 (1), p.21-32 |
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container_title | Ukrainian biochemical journal |
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creator | Zaitseva, O V Shandrenko, S G Veliky, M M |
description | This review focuses on the analysis of diagnostic value of the major bone remodeling markers, in particular synthesis and degradation markers of collagen type I. These include carboxy- and aminoterminal telopeptide, carboxy- and aminoterminal propeptide of procollagen type I, hydroxyproline, hydroxylysine, pyridinoline and deoxypyridinoline. Their measurement allows evaluating the structural and functional conditions and also the rate of metabolic processes in the bone tissue. The advantages and disadvantages of determination of these markers in the condition of different bone diseases were examined. It is shown that determination of bone collagen type I metabolism markers is the most informative for assessment of bone resorption, formation and turnover. |
doi_str_mv | 10.15407/ubj87.01.021 |
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It is shown that determination of bone collagen type I metabolism markers is the most informative for assessment of bone resorption, formation and turnover.</description><identifier>ISSN: 2409-4943</identifier><identifier>EISSN: 2413-5003</identifier><identifier>DOI: 10.15407/ubj87.01.021</identifier><identifier>PMID: 26036128</identifier><language>eng</language><publisher>Ukraine: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry</publisher><subject>Acid Phosphatase - metabolism ; Alkaline Phosphatase - metabolism ; Amino Acids - blood ; Amino Acids - urine ; Animals ; Biomarkers - blood ; Biomarkers - urine ; Bone and Bones - metabolism ; Bone and Bones - pathology ; Bone Density ; Bone Resorption - blood ; Bone Resorption - pathology ; Bone Resorption - urine ; Collagen Type I - metabolism ; Humans ; Hydroxylysine - blood ; Hydroxylysine - urine ; Hydroxyproline - blood ; Hydroxyproline - urine ; Osteocalcin - metabolism ; Peptide Fragments - blood ; Peptide Fragments - urine ; Procollagen - metabolism</subject><ispartof>Ukrainian biochemical journal, 2015, Vol.87 (1), p.21-32</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3131-ce22250ea0aefa4cc1f3f2c863ff372692dc82357047679d74a9e172fd4ae9363</citedby><cites>FETCH-LOGICAL-c3131-ce22250ea0aefa4cc1f3f2c863ff372692dc82357047679d74a9e172fd4ae9363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26036128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaitseva, O V</creatorcontrib><creatorcontrib>Shandrenko, S G</creatorcontrib><creatorcontrib>Veliky, M M</creatorcontrib><creatorcontrib>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv</creatorcontrib><title>Biochemical markers of bone collagen type I metabolism</title><title>Ukrainian biochemical journal</title><addtitle>Ukr Biochem J</addtitle><description>This review focuses on the analysis of diagnostic value of the major bone remodeling markers, in particular synthesis and degradation markers of collagen type I. 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It is shown that determination of bone collagen type I metabolism markers is the most informative for assessment of bone resorption, formation and turnover.</description><subject>Acid Phosphatase - metabolism</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Amino Acids - blood</subject><subject>Amino Acids - urine</subject><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone Density</subject><subject>Bone Resorption - blood</subject><subject>Bone Resorption - pathology</subject><subject>Bone Resorption - urine</subject><subject>Collagen Type I - metabolism</subject><subject>Humans</subject><subject>Hydroxylysine - blood</subject><subject>Hydroxylysine - urine</subject><subject>Hydroxyproline - blood</subject><subject>Hydroxyproline - urine</subject><subject>Osteocalcin - metabolism</subject><subject>Peptide Fragments - blood</subject><subject>Peptide Fragments - urine</subject><subject>Procollagen - metabolism</subject><issn>2409-4943</issn><issn>2413-5003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNo9kD1PwzAQhi0EoqgwsqKMLCl3_oxHqPiohMQCs-U4Z0hJ6hK3A_-etAWmO51ePXf3MHaJMEMlwdxs62VlZoAz4HjEzrhEUSoAcbzrwZbSSjFhFzkvAQAVN0JVp2zCNQiNvDpj-q5N4YP6Nviu6P3wSUMuUizqtKIipK7z77QqNt9rKhZFTxtfp67N_Tk7ib7LdPFbp-zt4f51_lQ-vzwu5rfPZRAosAzEOVdAHjxFL0PAKCIPlRYxCsO15U2ouFAGpNHGNkZ6S2h4bKQnK7SYssWB2yS_dOuhHU_8dsm3bj9Iw7vzw6YNHTmrfFB1CErWlbRkvCT0gmOlaq7I7ljXB9Z6SF9byhvXtznQ-OKK0jY71JUGg0rxMVoeomFIOQ8U_1cjuL15tzfvAN1ofsxf_aK3dU_Nf_rPs_gB5ex8UA</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Zaitseva, O V</creator><creator>Shandrenko, S G</creator><creator>Veliky, M M</creator><general>National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>2015</creationdate><title>Biochemical markers of bone collagen type I metabolism</title><author>Zaitseva, O V ; 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subjects | Acid Phosphatase - metabolism Alkaline Phosphatase - metabolism Amino Acids - blood Amino Acids - urine Animals Biomarkers - blood Biomarkers - urine Bone and Bones - metabolism Bone and Bones - pathology Bone Density Bone Resorption - blood Bone Resorption - pathology Bone Resorption - urine Collagen Type I - metabolism Humans Hydroxylysine - blood Hydroxylysine - urine Hydroxyproline - blood Hydroxyproline - urine Osteocalcin - metabolism Peptide Fragments - blood Peptide Fragments - urine Procollagen - metabolism |
title | Biochemical markers of bone collagen type I metabolism |
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