Controlled Intracellular Polymerization for Cancer Treatment

Numerous prodrugs have been developed and used for cancer treatments to reduce side effects and promote efficacy. In this work, we have developed a new photoactivatable prodrug system based on intracellular photoinduced electron transfer–reversible addition–fragmentation chain-transfer (PET–RAFT) po...

Full description

Saved in:
Bibliographic Details
Published in:JACS Au 2022-03, Vol.2 (3), p.579-589
Main Authors: Zhang, Yichuan, Gao, Quan, Li, Weishuo, He, Rongkun, Zhu, Liwei, Lian, Qianjin, Wang, Liang, Li, Yang, Bradley, Mark, Geng, Jin
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Numerous prodrugs have been developed and used for cancer treatments to reduce side effects and promote efficacy. In this work, we have developed a new photoactivatable prodrug system based on intracellular photoinduced electron transfer–reversible addition–fragmentation chain-transfer (PET–RAFT) polymerization. This unique polymerization process provided a platform for the synthesis of structure-predictable polymers with well-defined structures in living cells. The intracellularly generated poly­(N,N-dimethylacrylamide)­s were found to induce cell cycle arrest, apoptosis, and necroptosis, inhibit cell proliferation, and reduce cancer cell motilities. This polymerization-based “prodrug” system efficiently inhibits tumor growth and metastasis both in vitro and in vivo and will promote the development of targeted and directed cancer chemotherapy.
ISSN:2691-3704
2691-3704
DOI:10.1021/jacsau.1c00373