Controlled Intracellular Polymerization for Cancer Treatment

Numerous prodrugs have been developed and used for cancer treatments to reduce side effects and promote efficacy. In this work, we have developed a new photoactivatable prodrug system based on intracellular photoinduced electron transfer–reversible addition–fragmentation chain-transfer (PET–RAFT) po...

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Published in:JACS Au 2022-03, Vol.2 (3), p.579-589
Main Authors: Zhang, Yichuan, Gao, Quan, Li, Weishuo, He, Rongkun, Zhu, Liwei, Lian, Qianjin, Wang, Liang, Li, Yang, Bradley, Mark, Geng, Jin
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cited_by cdi_FETCH-LOGICAL-a491t-db6bfed126e4a6384ade9fae3cfbece8c4e5b16c137cdbf0568ab6293bb8a9a33
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container_title JACS Au
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creator Zhang, Yichuan
Gao, Quan
Li, Weishuo
He, Rongkun
Zhu, Liwei
Lian, Qianjin
Wang, Liang
Li, Yang
Bradley, Mark
Geng, Jin
description Numerous prodrugs have been developed and used for cancer treatments to reduce side effects and promote efficacy. In this work, we have developed a new photoactivatable prodrug system based on intracellular photoinduced electron transfer–reversible addition–fragmentation chain-transfer (PET–RAFT) polymerization. This unique polymerization process provided a platform for the synthesis of structure-predictable polymers with well-defined structures in living cells. The intracellularly generated poly­(N,N-dimethylacrylamide)­s were found to induce cell cycle arrest, apoptosis, and necroptosis, inhibit cell proliferation, and reduce cancer cell motilities. This polymerization-based “prodrug” system efficiently inhibits tumor growth and metastasis both in vitro and in vivo and will promote the development of targeted and directed cancer chemotherapy.
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title Controlled Intracellular Polymerization for Cancer Treatment
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