The role of garlic in hepatopulmonary syndrome: a randomized controlled trial

Increased nitric oxide production in cirrhosis has been commonly implicated in the genesis of hepatopulmonary syndrome (HPS). Initial studies suggested that garlic, a constituent of the daily diet, may have a role in the treatment of HPS by altering nitric oxide production. To evaluate the effects o...

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Bibliographic Details
Published in:Canadian journal of gastroenterology 2010-03, Vol.24 (3), p.183-188
Main Authors: De, Binay K, Dutta, Deep, Pal, Subrata K, Gangopadhyay, Subhabrata, Das Baksi, Sumanta, Pani, Adyapad
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Blood Gas Analysis
Double-Blind Method
Female
Follow-Up Studies
Garlic - chemistry
Hepatopulmonary Syndrome - drug therapy
Hepatopulmonary Syndrome - mortality
Hepatopulmonary Syndrome - physiopathology
Humans
Hypoxia - drug therapy
Hypoxia - etiology
Male
Middle Aged
Original
Oxygen - metabolism
Phytotherapy - methods
Young Adult
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Summary:Increased nitric oxide production in cirrhosis has been commonly implicated in the genesis of hepatopulmonary syndrome (HPS). Initial studies suggested that garlic, a constituent of the daily diet, may have a role in the treatment of HPS by altering nitric oxide production. To evaluate the effects of oral garlic supplementation on arterial blood gas parameters, and overall morbidity and mortality in patients with HPS. Twenty-one and 20 HPS patients were randomly assigned to receive either oral garlic supplementation or placebo, respectively, and were evaluated monthly over a period of nine to 18 months. After nine months, garlic supplementation was associated with a 24.66% increase in baseline arterial oxygen levels (83.05 mmHg versus 66.62 mmHg; P
ISSN:0835-7900
DOI:10.1155/2010/349076