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Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes

Solvents purification mainly used in pharmaceutical field such as acetone and methyl ethyl ketone (MEK) were performed through hybrid silica membranes and from binary and multi-components mixtures. Two hybrid silica membranes-zirconia doped bis(triethoxysilyl)methane and bis(triethoxysilyl)ethane (B...

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Published in:Membranes (Basel) 2019-07, Vol.9 (7), p.76
Main Authors: La Rocca, Thomas, Carretier, Emilie, Dhaler, Didier, Louradour, Eric, Truong, Thien, Moulin, Philippe
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description Solvents purification mainly used in pharmaceutical field such as acetone and methyl ethyl ketone (MEK) were performed through hybrid silica membranes and from binary and multi-components mixtures. Two hybrid silica membranes-zirconia doped bis(triethoxysilyl)methane and bis(triethoxysilyl)ethane (BTESE)-were studied. Flux, permeance, and separation factor were evaluated depending on temperature, composition, and number of organic compounds in the feed. Dehydration tests of acetone were operated at 30 and 45 °C following by acetone and MEK purification at 50 °C from multi-components hydro-organic mixtures where hydrophilic compounds (water, methanol) but also hydrophobic (dichloromethane (DCM) and/or toluene) were present. Results showed that the presence of Zr nanoparticles affected flux and improved selectivity in the case of dehydration. Experiments related to acetone and MEK purification, revealed a mass transfer alteration and a decrease of performance, from 99 to 97 wt% and from 98 to 95 wt% respectively, when the number of compounds in the initial feed grown up and more precisely, in the presence of DCM and toluene thus highlighting a possible coupling effect.
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subjects Acetone
Chemical engineering
Chemical Sciences
coupling effect
Dehydration
Dichloromethane
Ethane
Ethanol
Experiments
hybrid silica membrane
Hydrocarbons
Hydrophobicity
Mass transfer
Membranes
Methyl ethyl ketone
Nanoparticles
Organic compounds
Permeability
Pervaporation
Pharmaceutical industry
Pharmaceuticals
Purification
Reynolds number
Selectivity
Silica
Silicon dioxide
Solvents
solvents purification
Temperature effects
Toluene
Zirconia
Zirconium dioxide
title Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes
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