Treatment failure and associated factors among first line patients on highly active antiretroviral therapy in Ethiopia: a systematic review and meta-analysis

Antiretroviral therapy (ART) restores immune function and reduces human immunodeficiency virus (HIV) related adverse outcomes. The results of previous studies in Ethiopia were replete with inconsistent findings; nonexistence of national representative figures and determinant factors are found as sig...

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Bibliographic Details
Published in:Global health research and policy 2019-10, Vol.4 (1), p.32-10, Article 32
Main Authors: Assemie, Moges Agazhe, Alene, Muluneh, Ketema, Daniel Bekele, Mulatu, Selishi
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Drug resistance
Ethiopia
First-line treatment
Heterogeneity
HIV
HIV/AIDS
Human immunodeficiency virus
Immune response
Meta-analysis
Mortality
Switching to second-line
Treatment failure
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Summary:Antiretroviral therapy (ART) restores immune function and reduces human immunodeficiency virus (HIV) related adverse outcomes. The results of previous studies in Ethiopia were replete with inconsistent findings; nonexistence of national representative figures and determinant factors are found as significant gap. The aim of this systematic review and meta-analysis was to assess the existing evidence on ART treatment failure and associated factors in Ethiopia. Relevant studies on ART treatment failure were retrieved from international databases: PubMed, Google Scholar, Scopus, and Science Direct systematically prior to March 14, 2019. All identified studies reporting the proportion of first line treatment failure among HIV patients in Ethiopia were included. Two authors independently extracted all necessary data using a standardized data extraction format. A random-effects model was used to calculate pooled estimates and associated factors in Stata/se Version-14. The Cochrane Q test statistics and tests were used to assess the heterogeneity of the studies. From 18 articles reviewed; the pooled proportion of first line treatment failure among ART users in Ethiopia was 15.3% (95% CI: 12, 18.6) with (  = 97.9%,  
ISSN:2397-0642
2397-0642
DOI:10.1186/s41256-019-0120-4