Xpert MTB/RIF assay for diagnosis of extrapulmonary tuberculosis in children: a systematic review and meta-analysis

The Xpert® MTB/RIF assay (Xpert; Cepheid, Sunnyvale, CA, USA) is a cartridge-based nucleic acid amplification assay for rapidly diagnosing tuberculosis and assessing antibiotic sensitivity. Although previous evidence supports the use of Xpert for diagnosing extrapulmonary tuberculosis (EPTB) in adul...

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Bibliographic Details
Published in:BMC infectious diseases 2020-01, Vol.20 (1), p.14-14, Article 14
Main Authors: Seo, Young Seok, Kang, Ji-Man, Kim, Dong Soo, Ahn, Jong Gyun
Format: Article
Language:English
Subjects:
Accuracy
Acquired immune deficiency syndrome
Adolescent
AIDS
Antibiotics
Assaying
Bias
Biological Assay
Cartridges
Cerebrospinal fluid
Child
Children
Communicable diseases
Confidence intervals
Demographic aspects
Diagnosis
Diagnostic systems
Diseases
Extrapulmonary tuberculosis
HIV
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Lymph nodes
Lymphatic system
Male
Medical care quality
Meta-analysis
Methods
Microbiological assay
Molecular Diagnostic Techniques - methods
Molecular Diagnostic Techniques - standards
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Nucleic Acid Amplification Techniques - standards
Nucleic acids
Patients
Pediatric communicable diseases
Pediatrics
Physiological aspects
Quality
Reference Standards
Sensitivity analysis
Sensitivity and Specificity
Studies
Systematic review
Tuberculosis
Tuberculosis - diagnosis
Xpert MTB/RIF
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Description
Summary:The Xpert® MTB/RIF assay (Xpert; Cepheid, Sunnyvale, CA, USA) is a cartridge-based nucleic acid amplification assay for rapidly diagnosing tuberculosis and assessing antibiotic sensitivity. Although previous evidence supports the use of Xpert for diagnosing extrapulmonary tuberculosis (EPTB) in adults, information regarding the accuracy of Xpert for EPTB only in children is lacking. This meta-analysis was performed to assess the accuracy of Xpert for detecting EPTB in children. We searched the MEDLINE, EMBASE, and Cochrane Infectious Diseases Group Specialized Register from January 1, 2010 to July 16, 2019 for studies of the diagnostic performance wherein Xpert was analyzed against cultures or composite reference standards for
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-019-4745-1