Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff's Base Derivatives

A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine (2a,b) and corresponding Schiff's bases (3a–j) were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines (1a,b) as starting materials. The compounds 1a,...

Full description

Saved in:
Bibliographic Details
Published in:Journal of chemistry 2013-01, Vol.2013 (2013), p.1-6
Main Authors: Amr, Abd El-Galil E., al-Omar, Mohamed A., Flefel, Eman M., Sabry, Nermien M.
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine (2a,b) and corresponding Schiff's bases (3a–j) were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines (1a,b) as starting materials. The compounds 1a,b were reacted with 2,3,4,5-tetrachlorophthalic anhydride in glacial acetic acid to give the corresponding bis-imides (2a,b). But they are treated with aromatic aldehydes in refluxing ethanol to afford the Schiff’s base derivatives (3a–j). The antimicrobial screening showed that many of these newly synthesized compounds had good antimicrobial activities comparable to streptomycin and fusidic acid as positive controls. The detailed synthesis, spectroscopic data, and antimicrobial activities of the synthesized compounds were reported.
ISSN:2090-9063
2090-9071
DOI:10.1155/2013/106734