Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases

Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestrate the transcriptional regulation of genes involved in a variety of biological responses, such as energy metabolism and homeostasis, regulation of inflammation, cellular development, and differentiati...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-02, Vol.12 (4), p.650
Main Authors: Kim, In Soo, Silwal, Prashanta, Jo, Eun-Kyeong
Format: Article
Language:English
Subjects:
Antagonists
bacteria
Body fat
Chromosomes
Communicable Diseases
Cytokines
Drug targeting
Drug therapy
Energy metabolism
Fatty acids
Gene expression
Gene Expression Regulation
Gene regulation
Glucose
Homeostasis
Host-pathogen interactions
Humans
Immune response
Infection
Infections
Infectious diseases
Inflammation
Ligands
Lipids
Liver
Metabolism
Metabolites
Methods
Nuclear receptors
Oxidation
Oxidative stress
parasite
peroxisome proliferator-activated receptor
Peroxisome proliferator-activated receptors
Phosphorylation
PPAR alpha
Receptors, Cytoplasmic and Nuclear
Review
Roles
Transcription factors
Tumor necrosis factor-TNF
Tumorigenesis
virus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestrate the transcriptional regulation of genes involved in a variety of biological responses, such as energy metabolism and homeostasis, regulation of inflammation, cellular development, and differentiation. The many roles played by the PPAR signaling pathways indicate that PPARs may be useful targets for various human diseases, including metabolic and inflammatory conditions and tumors. Accumulating evidence suggests that each PPAR plays prominent but different roles in viral, bacterial, and parasitic infectious disease development. In this review, we discuss recent PPAR research works that are focused on how PPARs control various infections and immune responses. In addition, we describe the current and potential therapeutic uses of PPAR agonists/antagonists in the context of infectious diseases. A more comprehensive understanding of the roles played by PPARs in terms of host-pathogen interactions will yield potential adjunctive personalized therapies employing PPAR-modulating agents.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12040650