Murine malaria is associated with significant hearing impairment

Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice. Twenty mice were included in a stand...

Full description

Saved in:
Bibliographic Details
Published in:Malaria journal 2010-06, Vol.9 (1), p.159-159, Article 159
Main Authors: Schmutzhard, Joachim, Kositz, Christian H, Lackner, Peter, Dietmann, Anelia, Fischer, Marlene, Glueckert, Rudolf, Reindl, Markus, Stephan, Kurt, Riechelmann, Herbert, Schrott-Fischer, Annelies, Schmutzhard, Erich
Format: Article
Language:English
Subjects:
Animals
Audiometry
Brain stem
Brain Stem - physiology
Cognitive ability
Complications and side effects
Disease
Electrodes
Evoked Potentials, Auditory, Brain Stem - physiology
Hearing
Hearing loss
Hearing Loss - complications
Hearing Loss - parasitology
Hearing Tests
Human diseases
Infections
Laboratory animals
Malaria
Malaria, Cerebral - complications
Malaria, Cerebral - parasitology
Malaria, Cerebral - physiopathology
Mice
Mice, Inbred C57BL
Plasmodium berghei - isolation & purification
Plasmodium falciparum
Risk factors
Survival
Vector-borne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice. Twenty mice were included in a standardized murine cerebral malaria model. Auditory evoked brainstem responses were assessed before infection and at the peak of the illness. A significant hearing impairment could be demonstrated in mice with malaria, especially the cerebral form. The control group did not show any alterations. No therapy was used. This suggests that malaria itself leads to a hearing impairment in mice.
ISSN:1475-2875
1475-2875
DOI:10.1186/1475-2875-9-159