Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients

Higher blood malondialdehyde (biomarker of lipid peroxidation) levels in the first hours of traumatic brain injury (TBI) have been found in patients with a worst prognosis. The objective of this study was to determine whether serum malondialdehyde levels during the first week of severe TBI could be...

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Bibliographic Details
Published in:BMC research notes 2019-12, Vol.12 (1), p.789-789, Article 789
Main Authors: Lorente, Leonardo, Martín, María M, Abreu-González, Pedro, Ramos, Luis, Cáceres, Juan J, Argueso, Mónica, Solé-Violán, Jordi, Jiménez, Alejandro, García-Marín, Victor
Format: Article
Language:English
Subjects:
Adult
Age
Antioxidants
Biological markers
Biomarkers
Biomarkers - blood
Brain injuries
Brain Injuries, Traumatic - blood
Brain Injuries, Traumatic - mortality
Brain trauma
Catheters
Coma
Female
Humans
Injury
Intensive care units
Lipid peroxidation
Lipids
Male
Malondialdehyde
Malondialdehyde - blood
Melatonin
Memantine
Middle Aged
Mortality
Patients
Prognosis
Prospective Studies
Regression analysis
Research Note
Spain - epidemiology
Studies
Survival Analysis
Trauma
Traumatic brain injury
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Summary:Higher blood malondialdehyde (biomarker of lipid peroxidation) levels in the first hours of traumatic brain injury (TBI) have been found in patients with a worst prognosis. The objective of this study was to determine whether serum malondialdehyde levels during the first week of severe TBI could be used as mortality biomarkers. This was a multicenter, prospective and observational study performed in six Spanish Intensive Care Units. We included patients with severe TBI (defined as Glasgow Coma Scale 
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-019-4828-5