Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke

Ischemic stroke is one of the major contributors to death and disability worldwide. Thus, there is an urgent need to develop early brain tissue perfusion therapies following acute stroke and to enhance functional recovery in stroke survivors. The morbidity, therapy, and recovery processes are highly...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2022-12, Vol.10, p.980548-980548
Main Authors: Jin, Meiqi, Zhang, Shuxia, Wang, Mengchen, Li, Qiaoyu, Ren, Jiahui, Luo, Yun, Sun, Xiaobo
Format: Article
Language:English
Subjects:
Bioengineering and Biotechnology
blood vessels
exosomes
inflammation
ischemic stroke
neuron
the blood-brain barrier (BBB)
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Summary:Ischemic stroke is one of the major contributors to death and disability worldwide. Thus, there is an urgent need to develop early brain tissue perfusion therapies following acute stroke and to enhance functional recovery in stroke survivors. The morbidity, therapy, and recovery processes are highly orchestrated interactions involving the brain with other tissues. Exosomes are natural and ideal mediators of intercellular information transfer and recognized as biomarkers for disease diagnosis and prognosis. Changes in exosome contents express throughout the physiological process. Accumulating evidence demonstrates the use of exosomes in exploring unknown cellular and molecular mechanisms of intercellular communication and organ homeostasis and indicates their potential role in ischemic stroke. Inspired by the unique properties of exosomes, this review focuses on the communication, diagnosis, and therapeutic role of various derived exosomes, and their development and challenges for the treatment of cerebral ischemic stroke.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.980548