Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue

This study evaluated modulators of apoptosis in the myocardium of rats subjected to exercise training. Rats were assigned to non-trained and exercise-trained groups, respectively. The animals ran for 1 h per day, 6 times per week and, for a total of 13 weeks. The left ventricle was processed for ana...

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Published in:Motriz : Revista de Educação Física. Unesp 2014-06, Vol.20 (2), p.233-238
Main Authors: Santana, Eduardo Tadeu, Serra, Andrey Jorge, Silva Junior, José Antonio, Bocalini, Danilo Sales, Barauna, Valério Garrone, Krieger, José Eduardo, Tucci, Paulo José Ferreira
Format: Article
Language:English
Subjects:
apoptosis
el entrenamiento físico
miocardio
SPORT SCIENCES
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Summary:This study evaluated modulators of apoptosis in the myocardium of rats subjected to exercise training. Rats were assigned to non-trained and exercise-trained groups, respectively. The animals ran for 1 h per day, 6 times per week and, for a total of 13 weeks. The left ventricle was processed for analysis of gene and protein anti- (Bcl-2, c-IAP1, c-IAP2, Survivin, ILK, Akt and pAkt) and pro- (Bad) apoptotic expression by real-time PCR (except for Akt and pAkt) and Western blot, respectively. The Bad mRNA (p
ISSN:1980-6574
1980-6574
DOI:10.1590/S1980-65742014000200015