Pre-S1 Mutations as Indicated by Serum Pre-S1 Antigen Negative is Associated with an Increased Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients

Pre-S1 antigen (pre-S1) is a component of hepatitis B virus large surface antigen (L-HBsAg). This study aimed to investigate the association between clinical pre-S1 antigen (pre-S1) status and adverse prognostic events in chronic hepatitis B (CHB) patients. This study retrospectively enrolled 840 CH...

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Bibliographic Details
Published in:Journal of hepatocellular carcinoma 2023, Vol.10, p.599-609
Main Authors: Zhang, Xingxin, Gu, Chenjian, Wei, Qian, Cao, Yirong, She, Weimin, Shi, Hong, Xie, Youhua, Guo, Jinsheng
Format: Article
Language:English
Subjects:
Amino acids
Antigens
Biomarkers
Biopsy
chronic hepatitis b
Clinical significance
Endoplasmic reticulum
Frameshift mutation
Gene deletion
Genomes
Hepatitis B
Hepatitis B surface antigen
Hepatocellular carcinoma
Infections
Liver cancer
Liver cirrhosis
Liver diseases
Magnetic resonance imaging
Mutation
Nucleotide sequence
Original Research
Patients
Polymerase chain reaction
Pre-S1 antigen
Proteins
Statistical analysis
Tomography
Ultrasonic imaging
Viruses
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Summary:Pre-S1 antigen (pre-S1) is a component of hepatitis B virus large surface antigen (L-HBsAg). This study aimed to investigate the association between clinical pre-S1 antigen (pre-S1) status and adverse prognostic events in chronic hepatitis B (CHB) patients. This study retrospectively enrolled 840 CHB patients with comprehensive clinical data, including 144 patients with multiple follow-up of pre-S1 status. All patients were tested for serum pre-S1 and divided into pre-S1 positive and negative groups. Single factor and logistic multiple regression analyses were performed to explore the association between pre-S1 and other HBV biomarkers with the risk of hepatocellular carcinoma (HCC) in CHB patients. The pre-S1 region sequences of HBV DNA were obtained from one pre-S1 positive and two pre-S1 negative treatment-naïve patients using polymerase chain reaction (PCR) amplification followed by Sanger sequencing. The quantitative HBsAg level was significantly higher in the pre-S1 positive group than that in the pre-S1 negative group (Z=-15.983,
ISSN:2253-5969
2253-5969
DOI:10.2147/JHC.S373333