Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates

A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium salt derivatives 2 and 5, which were tr...

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Bibliographic Details
Published in:Journal of chemistry 2018-01, Vol.2018 (2018), p.1-9
Main Authors: al-Omar, Mohamed A., Amr, Abd El-Galil E., Elnaggar, Dina H., El-Shorbagi, Abdel-Nasser, El-Naggar, Mohamed, Elsayed, Elsayed A.
Format: Article
Language:English
Subjects:
Anticancer properties
Antimicrobial agents
Arthritis
Cancer
Cell cycle
Chemistry
Chromatography
Cytotoxicity
Derivatives
Methyl salicylate
Nitrogen
NMR
Nuclear magnetic resonance
Pharmacology
Sodium nitrite
Substitutes
Synthesis
Toxicology
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Summary:A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium salt derivatives 2 and 5, which were treated with substituted imino or substituted amino derivatives, to give the corresponding substituted amino-pent-2-en-3-yl-diazenylbenzoate 4a–k or 2-substituted-1-(naphthalen-1-yl)diazene derivatives 6a–h, 7a,b, and 8a,b. All the synthesized compounds were elucidated by elemental analysis and spectroscopic evidence.
ISSN:2090-9063
2090-9071
DOI:10.1155/2018/3626824