Is the platelet-to-lymphocyte ratio a new prognostic marker in multiple myeloma?

ABSTRACT BACKGROUND: Recent reports showed neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), as a predictor of progression-free survival (PFS) and overall survival (OS) in various malignancies. MATERIALS AND METHODS: We retrospectively...

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Published in:Journal of laboratory physicians 2018-10, Vol.10 (4), p.363-369
Main Authors: Solmaz, Serife, Uzun, Ozcan, Acar, Celal, Sevindik, Omur Gokmen, Piskin, Ozden, Ozsan, Hayri Guner, Demirkan, Fatih, Undar, Bulent, Alacacioglu, Ahmet, Ozcan, Mehmet Ali, Alacacioglu, Inci
Format: Article
Language:English
Subjects:
Blood platelets
Bone marrow
Care and treatment
Cytokines
Development and progression
Growth factors
Lymphocytes
Medical prognosis
Medical research
Multiple myeloma
Multivariate analysis
neutrophil-to-lymphocyte ratio
Neutrophils
new prognostic marker
Original
Original Article
platelet-to-lymphocyte ratio
Prognosis
Studies
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Summary:ABSTRACT BACKGROUND: Recent reports showed neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), as a predictor of progression-free survival (PFS) and overall survival (OS) in various malignancies. MATERIALS AND METHODS: We retrospectively examined the PLR, NLR, and MLR in a cohort of 186 newly diagnosed multiple myeloma (MM) patients. This study investigated the prognostic relevance of NLR, PLR, and MLR in MM patients. NLR, PLR, and MLR were calculated from whole blood counts before therapy. The Kaplan–Meier curves and multivariate Cox models were used for the evaluation of survival. RESULTS: Applying cutoff of 1.9 (NLR), 120.00 (PLR), and 0.27 (MLR), decreased PLR showed a negative impact on the outcome. Decreased PLR is an independent predictor for PFS and OS. There were no significant differences in median survival between the high and low NLR ( P = 0.80) and MLR ( P = 0.87) groups. CONCLUSIONS: In this study, thrombocytopenia and low PLR are associated with poor survival in MM patients does this P value apply to thrombocytopenia or low PLR and may serve as the cost-effective prognostic biomarker.
ISSN:0974-2727
0974-7826
DOI:10.4103/JLP.JLP_36_18