Correlation of serum estradiol level on the day of ovulation trigger with the reproductive outcome of intracytoplasmic sperm injection

• Published in: Journal of human reproductive sciences 2016-01, Vol.9 (1), p.23-27
• Main Authors: Siddhartha, N, Reddy, N, Pandurangi, Monna, Tamizharasi, M, Radha, V, Kanimozhi, K
• Format: Article
• Language: English
• Subjects: Analysis; Body mass index; Embryo quality; Embryo transplantation; Embryos; Estradiol; fertilization; hCG; Health aspects; implantation; In vitro fertilization; Infertility; Influence; intracytoplasmic sperm injection; Medicine; oocyte; Original; ovulation trigger; Patients; Pregnancy; Quality; Reproductive health; Sperm; Studies; Ultrasonic imaging
• ISSN: 0974-1208; 1998-4766
• DOI: 10.4103/0974-1208.178631

BACKGROUND: Serum estradiol (E2) levels are measured in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), to assess the ovarian response and to predict ovarian hyperstimulation syndrome. The impact of peak E2levels on IVF-ICSI outcome was found to be inconsistent in the previous studies. AIM: To evaluate the impact of the serum E2levels on the day of ovulation trigger with the reproductive outcome of ICSI. SETTINGS AND DESIGN: Retrospective observational study. ART Center, at a Tertiary Care University Teaching Hospital. SUBJECTS AND METHODS: Eighty-nine infertile women, who underwent ICSI with fresh embryo transfer over a period of 3 years, were included in the study. The study subjects were grouped based on the serum E2level on the day of ovulation trigger:- Group I - 4000 pg/ml. The baseline characteristics and controlled ovarian hyperstimulation (COH) outcome were compared among the study groups. STATISTICAL ANALYSIS USED: Chi-square test, Student's t-test, ANOVA, and logistic regression analysis. RESULTS: The study groups were comparable with regard to age, body mass index, ovarian reserve. Group V had significantly higher number of oocytes retrieved than I and II (18.90 vs. 11.36 and 11.33; P = 0.009). Group IV showed significantly higher fertilization rate than I, III, and V; (92.23 vs. 77.43, 75.52, 75.73; P = 0.028). There were no significant differences in the implantation rates (P = 0.368) and pregnancy rates (P = 0.368). CONCLUSION: Higher E2levels on the day of ovulation trigger would predict increased oocyte yield after COH. E2levels in the range of 3000-4000 pg/ml would probably predict increased fertilization and pregnancies in ICSI cycles.