Chotosan, a Kampo Formula, Ameliorates Hippocampal LTD and Cognitive Deficits in Juvenile-Onset Diabetes Rats

Childhood-onset type 1 diabetes is associated with modest impairments in cognition and has an elevated risk of cognitive decline. Our previous study showed that working memory and hippocampal long-term depression (LTD) were impaired in juvenile-onset diabetes mellitus (JDM) rats. In this study, we i...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2014/02/20, Vol.124(2), pp.192-200
Main Authors: Sasaki-Hamada, Sachie, Tamaki, Keita, Otsuka, Hayuma, Ueno, Tatsuto, Sacai, Hiroaki, Niu, Yimin, Matsumoto, Kinzo, Oka, Jun-Ichiro
Format: Article
Language:English
Subjects:
Animals
chotosan
Cognition Disorders - drug therapy
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 1 - complications
Disease Models, Animal
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
hippocampal synaptic plasticity
Long-Term Synaptic Depression - drug effects
Male
Medicine, Kampo
Memory - drug effects
NR2B subunit
Phytotherapy
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - metabolism
Risk
Streptozocin
streptozotocin-induced diabetes
working memory
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Summary:Childhood-onset type 1 diabetes is associated with modest impairments in cognition and has an elevated risk of cognitive decline. Our previous study showed that working memory and hippocampal long-term depression (LTD) were impaired in juvenile-onset diabetes mellitus (JDM) rats. In this study, we investigated the effect of chotosan (CTS), a traditional herbal formula called a Kampo medicine, which has been clinically demonstrated to be effective for the treatment of vascular dementia, on JDM rats. The repeated treatment with CTS (1 g/kg per day) for 3 – 7 days restored spatial working memory and hippocampal LTD in JDM rats. The expression level of NR2B glutamate receptor subunits, but not other glutamate receptor subunits was enhanced in the hippocampus of JDM rats, and repeated treatment with CTS reversed these changes. These results suggest that CTS improves diabetes-induced cognitive deficits by modulating NMDA-receptor subunit expression.
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.13179FP