Chemokines and chemokine receptors in Behçet's disease

Behçet's disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and t...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2023-01, Vol.14, p.1109147
Main Authors: Li, Zhan, Cheng, Linlin, Zhan, Haoting, Li, Yongzhe
Format: Article
Language:English
Subjects:
Behcet Syndrome - pathology
Behçet’s disease
cell infiltration
chemokine
chemokine receptor
Chemokines
Humans
Immunology
Intestines - pathology
Receptors, Chemokine
therapeutic target
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Behçet's disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and there are no effective laboratory markers for the diagnosis of BD. In addition, BD is presently incurable. Chemokines, a family of small secreted chemotactic cytokines, interact with chemokine receptors and mediate the migration, localization and cellular interactions of inflammatory cells. Several studies have suggested that chemokines and their receptors play an important role in the occurrence and development of BD and that these chemokines along with their receptors can be utilized as biomarkers and therapeutic targets. In the present review, chemokines and chemokine receptors involved in BD and their potential application in diagnosis and therapy have been discussed.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1109147