Skin Manifestations and Coeliac Disease in Paediatric Population

Celiac disease (CD) is an immune-mediated enteropathy caused by gluten ingestion, affecting approximately 1% of the worldwide population. Extraintestinal symptoms may be present as the first signs of CD, years before the CD diagnosis is made. A great variety of extraintestinal manifestations may be...

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Bibliographic Details
Published in:Nutrients 2021-10, Vol.13 (10), p.3611
Main Authors: Persechino, Flavia, Galli, Gloria, Persechino, Severino, Valitutti, Francesco, Zenzeri, Letizia, Mauro, Angela, Corleto, Vito Domenico, Parisi, Pasquale, Ziparo, Chiara, Evangelisti, Melania, Quatrale, Giovanna, Di Nardo, Giovanni
Format: Article
Language:English
Subjects:
Adults
Antibodies
Atopic dermatitis
Autoimmune diseases
Biopsy
Celiac disease
Children
coeliac disease
Cytokines
Dermatitis
Dermatitis herpetiformis
Diabetes
Diagnosis
Eczema
Gluten
Ingestion
Patients
Pediatrics
Physicians
Population
Psoriasis
Purpura
Review
Signs and symptoms
Skin
Skin diseases
skin manifestation
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Summary:Celiac disease (CD) is an immune-mediated enteropathy caused by gluten ingestion, affecting approximately 1% of the worldwide population. Extraintestinal symptoms may be present as the first signs of CD, years before the CD diagnosis is made. A great variety of extraintestinal manifestations may be associated with CD. Cutaneous manifestations represent the main extraintestinal manifestations, with dermatitis herpetiformis being the most common in patients with CD. In adults, it has been demonstrated that the role of a gluten-free diet is crucial not only for the recovery of signs and symptoms associated with CD but also for cutaneous manifestations, which often improve after gluten avoidance. In children with CD, the association with skin disorders is well documented regarding dermatitis herpetiformis, but studies considering other dermatological conditions, such as psoriasis and atopic dermatitis, are few. The prevalence and manifestations of dermatological disorders in celiac children are often different from those in adults, explaining the gap between these populations. In addition, the therapeutic role of a gluten-free diet in the improvement in skin alterations is not fully understood in children and in adult population except for dermatitis herpetiformis. Therefore, cutaneous CD symptoms need to be known and recognized by physicians despite their specialties to improve early CD diagnosis, which is critical for a better prognosis. This review describes the current scientific evidence on skin manifestations associated with CD in the pediatric population.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13103611