Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen

Among non-human mammals, exposure to androgens during critical periods of development leads to gynephilia (attraction to females), whereas the absence or low levels of prenatal androgens leads to androphilia (attraction to males). However, in humans, retrospective markers of prenatal androgens have...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.8102-8102, Article 8102
Main Authors: Swift-Gallant, Ashlyn, Di Rita, Victor, Major, Christina A., Breedlove, Christopher J., Jordan, Cynthia L., Breedlove, S. Marc
Format: Article
Language:English
Subjects:
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Anal sex
Androgens
Females
Gender
Heterogeneity
Humanities and Social Sciences
multidisciplinary
Prenatal experience
Science
Science (multidisciplinary)
Sex differentiation
Sex role
Sexual behavior
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Summary:Among non-human mammals, exposure to androgens during critical periods of development leads to gynephilia (attraction to females), whereas the absence or low levels of prenatal androgens leads to androphilia (attraction to males). However, in humans, retrospective markers of prenatal androgens have only been associated with gynephilia among women, but not with androphilia among men. Here, we asked whether an indirect indication of prenatal androgen exposure, 2D:4D, differs between subsets of gay men delineated by anal sex role (ASR). ASR was used as a proxy for subgroups because ASR groups tend to differ in other measures affected by brain sexual differentiation, such as gender conformity. First, we replicated the finding that gay men with a receptive ASR preference (bottoms) report greater gender nonconformity (GNC) compared to gay men with an insertive ASR preference (tops). We then found that Tops have a lower (male-typical) average right-hand digit ratio than Bottoms, and that among all gay men the right-hand 2D:4D correlated with GNC, indicating that a higher (female-typical) 2D:4D is associated with increased GNC. Differences were found between non-exclusive and exclusive same-sex attraction and GNC, and ASR group differences on digit ratios do not reach significance when all non-heterosexual men are included in the analyses, suggesting greater heterogeneity in the development of non-exclusive same-sex sexual orientations. Overall, results support a role for prenatal androgens, as approximated by digit ratios, in influencing the sexual orientation and GNC of a subset of gay men.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-87338-0