Interaction between adipocytes and high-density lipoprotein:new insights into the mechanism of obesity-induced dyslipidemia and atherosclerosis

Obesity is the most common nutritional disorder worldwide and is associated with dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in obesity is low high density lipoprotein (HDL) cholesterol (HDL-C) levels. Moreover, the quality of HDL is also changed in the obes...

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Bibliographic Details
Published in:Lipids in health and disease 2019-12, Vol.18 (1), p.223-223, Article 223
Main Authors: Zhang, Tianhua, Chen, Jin, Tang, Xiaoyu, Luo, Qin, Xu, Danyan, Yu, Bilian
Format: Article
Language:English
Subjects:
Abdomen
Adipocyte
Adipocytes
Adipocytes - physiology
Adipose tissue
Adipose Tissue - physiopathology
Animals
Apolipoprotein A-I - physiology
Arteriosclerosis
Atherosclerosis
Atherosclerosis - etiology
Atherosclerosis - physiopathology
Atherosclerosis - prevention & control
Body fat
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Cholesterol, HDL - blood
Cytokines
Dyslipidemia
Dyslipidemias - etiology
Dyslipidemias - physiopathology
Energy
Energy management
Energy storage
Fatty acids
Female
HDL
High density lipoprotein
Hormones
Humans
Insulin resistance
Lipids
Lipolysis
Lipoproteins
Lipoproteins, HDL - physiology
Liver
Male
Metabolic disorders
Metabolism
Obesity
Obesity - complications
Physiological aspects
Proteins
Review
Thermogenesis
Triglycerides
Tumor necrosis factor-TNF
Type 2 diabetes
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Description
Summary:Obesity is the most common nutritional disorder worldwide and is associated with dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in obesity is low high density lipoprotein (HDL) cholesterol (HDL-C) levels. Moreover, the quality of HDL is also changed in the obese setting. However, there are still some disputes on the explanations for this phenomenon. There is increasing evidence that adipose tissue, as an energy storage tissue, participates in several metabolism activities, such as hormone secretion and cholesterol efflux. It can influence overall reverse cholesterol transport and plasma HDL-C level. In obesity individuals, the changes in morphology and function of adipose tissue affect plasma HDL-C levels and HDL function, thus, adipose tissue should be the main target for the treatment of HDL metabolism in obesity. In this review, we will summarize the cross-talk between adipocytes and HDL related to cardiovascular disease and focus on the new insights of the potential mechanism underlying obesity and HDL dysfunction.
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-019-1170-9