Metabolites of Geum aleppicum and Sibbaldianthe bifurca : Diversity and α-Glucosidase Inhibitory Potential

α-Glucosidase inhibitors are essential in the treatment of diabetes mellitus. Plant-derived drugs are promising sources of new compounds with glucosidase-inhibiting ability. The Jacq. and (L.) Kurtto & T.Erikss. herbs are used in many traditional medical systems to treat diabetes. In this study,...

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Bibliographic Details
Published in:Metabolites 2023-05, Vol.13 (6), p.689
Main Authors: Kashchenko, Nina I, Olennikov, Daniil N, Chirikova, Nadezhda K
Format: Article
Language:English
Subjects:
Acids
avens
Carbohydrates
Chromatography
Diabetes
Diabetes mellitus
Ellagic acid
Flavonoids
Flowering
Flowers & plants
Fruits
Geum aleppicum
Herbs
High-performance liquid chromatography
Ionization
Ions
Metabolites
Organic acids
Plants
Potentilla bifurca
Quercetin
Rosaceae
Sibbaldianthe bifurca
Triterpenoids
α-Glucosidase
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Summary:α-Glucosidase inhibitors are essential in the treatment of diabetes mellitus. Plant-derived drugs are promising sources of new compounds with glucosidase-inhibiting ability. The Jacq. and (L.) Kurtto & T.Erikss. herbs are used in many traditional medical systems to treat diabetes. In this study, metabolites of the and herbs in active growth, flowering, and fruiting stages were investigated using high-performance liquid chromatography with photodiode array and electrospray ionization triple quadrupole mass spectrometric detection (HPLC-PDA-ESI-tQ-MS/MS). In total, 29 compounds in and 41 components in were identified including carbohydrates, organic acids, benzoic and ellagic acid derivatives, ellagitannins, flavonoids, and triterpenoids. Gemin A, miquelianin, niga-ichigoside F1, and 3,4-dihydroxybenzoic acid 4- -glucoside were the dominant compounds in the herb, while guaiaverin, miquelianin, tellimagrandin II , casuarictin, and glucose were prevailing compounds in the herb. On the basis of HPLC activity-based profiling of the herb extract, the most pronounced inhibition of α-glucosidase was observed for gemin A and quercetin-3- -glucuronide. The latter compound and quercetin-3- -arabinoside demonstrated maximal inhibition of α-glucosidase in the herb extract. The obtained results confirm the prospects of using these plant compounds as possible sources of hypoglycemic nutraceuticals.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo13060689