Parkinson's Disease in Light of the COVID-19 Pandemic

In this review we attempt to collate the existing scientific evidence regarding the possible role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathophysiology of Parkinson's disease (PD), as well as to investigate the impact of PD/parkinsonism on the clinical course of...

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Bibliographic Details
Published in:Brain sciences 2022-01, Vol.12 (2), p.143
Main Authors: Drelich-Zbroja, Anna, Cheda, Mateusz, Kuczyńska, Maryla, Dąbrowska, Izabela, Kopyto, Ewa, Halczuk, Izabela
Format: Article
Language:English
Subjects:
Aldosterone
Angiotensin
Basal ganglia
Central nervous system diseases
Coronaviruses
Cough
COVID-19
Dysbacteriosis
Dyspnea
Etiology
Influenza
Intestinal microflora
Meta-analysis
Microbiomes
Movement disorders
Muscles
Neurodegeneration
Neurodegenerative diseases
Pandemics
Parkinson's disease
parkinsonism
Renin
Respiration
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
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Summary:In this review we attempt to collate the existing scientific evidence regarding the possible role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathophysiology of Parkinson's disease (PD), as well as to investigate the impact of PD/parkinsonism on the clinical course of the viral infection itself. Since etiology of PD is not completely understood, various studies suggest different potential links between coronavirus disease 2019 (COVID-19) and PD. Suggested connections include, among others, similar prodromal symptoms, renin-angiotensin-aldosterone system involvement, or gut microbiome dysbiosis participation. Despite the initial assumptions that, as a mainly elderly population suffering from rigidity of respiratory muscles, impairment of cough reflex, and dyspnea, PD patients would be more susceptible to viral infection, and would experience a more aggressive course of COVID-19, the published scientific reports contain mutually exclusive data that require further investigation and meta-analysis.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci12020143