Pristine/folate-functionalized graphene oxide as two intrinsically radioiodinated nano-theranostics: self/dual in vivo targeting comparative study

Background Nanomedicine offers great potentials for theranostic studies via providing higher efficacy and safety levels. This work aimed to develop and evaluate a new nanoplatform as a tumor theranostic probe. Results Carboxyl-functionalized graphene oxide nanosheets (FGO) was well synthesized from...

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Bibliographic Details
Published in:Cancer nanotechnology 2023-12, Vol.14 (1), p.6-17, Article 6
Main Authors: Swidan, Mohamed M., Essa, Basma M., Sakr, Tamer M.
Format: Article
Language:English
Subjects:
Biochemistry
Biocompatibility
Biomedical Engineering and Bioengineering
Cancer Research
Cerium gadolinium oxides
Chemistry and Materials Science
Comparative studies
Folic acid
Graphene
Graphene oxide nanosheets
In vivo methods and tests
Intrinsic radioiodination
Materials Science
Nanoplatform
Nanostructure
Nanotechnology
Radioactive tracers
Theranostic
Toxicity
Tumor
Tumors
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Summary:Background Nanomedicine offers great potentials for theranostic studies via providing higher efficacy and safety levels. This work aimed to develop and evaluate a new nanoplatform as a tumor theranostic probe. Results Carboxyl-functionalized graphene oxide nanosheets (FGO) was well synthesized from graphite powder and then conjugated with folic acid to act as a targeted nano-probe. Full characterization and in vitro cytotoxicity evaluation were conducted; besides, in vivo bio-evaluation was attained via intrinsic radioiodination approach in both normal and tumor-bearing Albino mice. The results indicated that FGO as well as conjugated graphene oxide nanosheets (CGO) are comparatively non-toxic to normal cells even at higher concentrations. Pharmacokinetics of FGO and CGO showed intensive and selective uptake in the tumor sites where CGO showed high T/NT of 7.27 that was 4 folds of FGO at 1 h post injection. Additionally, radioiodinated-CGO (ICGO) had declared a superior prominence over the previously published tumor targeted GO radiotracers regarding the physicochemical properties pertaining ability and tumor accumulation behavior. Conclusions In conclusion, ICGO can be used as a selective tumor targeting agent for cancer theranosis with aid of I-131 that has a maximum beta and gamma energies of 606.3 and 364.5 keV, respectively.
ISSN:1868-6958
1868-6966
DOI:10.1186/s12645-023-00157-y