Association between adherence to life's simple 7 metrics and risk of obstructive sleep apnea among adults in the United States

• Published in: BMC psychiatry 2024-08, Vol.24 (1), p.560-13, Article 560
• Main Authors: Wu, Shuang, Yang, Yan-Min, Zhu, Jun, Wang, Lu-Lu, Xu, Wei, Lyu, Si-Qi, Wang, Juan, Shao, Xing-Hui, Zhang, Han
• Format: Article
• Language: English
• Subjects: Adult; Adults; Aged; Antihypertensives; Apnea; Blood pressure; Body mass index; C-reactive protein; Cardiac arrhythmia; Cardiovascular disease; Cholesterol; Chronic illnesses; Cross-Sectional Studies; Exercise; Fatty acids; Female; Glucose; Humans; Hypertension; Inflammation; Inflammation - epidemiology; Institutionalization; Interviews; Leukocytes (neutrophilic); Life’s simple 7 metrics; Male; Mediation; Middle Aged; NHANES; Nutrition research; Nutrition Surveys; Nutritional status; Obesity; Obstructive sleep apnea; Questionnaires; Regression analysis; Risk Factors; Self report; Sleep apnea; Sleep apnea syndromes; Sleep Apnea, Obstructive - epidemiology; Sleep disorders; Surveys; United States - epidemiology; Young Adult
• ISSN: 1471-244X; 1471-244X
• DOI: 10.1186/s12888-024-05990-y

We aimed to explore the impact of adherence to Life's Simple 7 (LS7) metrics on risk of obstructive sleep apnea (OSA), and the impact of inflammation on the association, in adults in the United States. Data from 13,825 community-dwelling adults aged ≥ 20 years recruited in the National Health and Nutrition Examination Surveys (NHANES) 2005-2008, 2015-2018 was analyzed. The LS7 score was calculated based on the AHA definition of LS7 metrics. The diagnosis of OSA was based on self-reported symptoms of sleep disturbance using a standard questionnaire. The Multivariable Apnea Prediction (MAP) Index score was also calculated to assess the risk of OSA. Log-binominal regression and negative binomial regression were performed to estimate the associations between LS7 and OSA and MAP index, with odds ratios (ORs) and prevalence ratios (PRs) and their 95% confidence intervals (CIs) calculated. Mediation analysis was performed to estimate the mediating effects of inflammatory indicators on the associations. A total of 4473 participants (32.4%) had OSA, and the mean MAP index was 0.39. In fully adjusted log-binominal regression models, with total score  8, respectively (P for trend