To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis

Cystic fibrosis (CF) lung disease is characterised by recurring bacterial infections resulting in inflammation, lung damage and ultimately respiratory failure. is considered one of the most important lung pathogens in those with cystic fibrosis. While multiple cystic fibrosis animal models have been...

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Bibliographic Details
Published in:Frontiers in physiology 2023-02, Vol.14, p.1104856-1104856
Main Authors: Reyne, Nicole, McCarron, Alexandra, Cmielewski, Patricia, Parsons, David, Donnelley, Martin
Format: Article
Language:English
Subjects:
animal models
cystic fibrosis
lung disease
lung infection
Physiology
Pseudomonas aeruginosa
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Summary:Cystic fibrosis (CF) lung disease is characterised by recurring bacterial infections resulting in inflammation, lung damage and ultimately respiratory failure. is considered one of the most important lung pathogens in those with cystic fibrosis. While multiple cystic fibrosis animal models have been developed, many fail to mirror the cystic fibrosis lung disease of humans, including the colonisation by opportunistic environmental pathogens. Delivering bacteria to the lungs of animals in different forms is a way to model cystic fibrosis bacterial lung infections and disease. This review presents an overview of previous models, and factors to consider when generating a new lung infection model. The future development and application of lung infection models that more accurately reflect human cystic fibrosis lung disease has the potential to assist in understanding the pathophysiology of cystic fibrosis lung disease and for developing treatments.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2023.1104856