The role of NOS3-rs1799983 and NOS3- rs2070744 SNP in occurrence of avascular necrosis as a post COVID-19 complication

Avascular necrosis (AVN) is a debilitating condition characterized by bone tissue death due to inadequate blood supply, leading to joint dysfunction and collapse. This study investigates the potential association between AVN and COVID-19, focusing on genetic factors such as NOS3 polymorphisms. A tot...

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Bibliographic Details
Published in:BMC medical genomics 2024-08, Vol.17 (1), p.217-8
Main Authors: Fouda, Eman Abd Allah Mahmoud, Badr, Eman Ae, Gawesh, Doaa, Mahmoud, Mohammad A
Format: Article
Language:English
Subjects:
Avascular necrosis
Biochemical markers
Blood pressure
Case-Control Studies
COVID-19
COVID-19 - complications
COVID-19 - genetics
COVID-19 - pathology
Ethics
Female
Gene polymorphism
Genetic analysis
Genetic factors
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Health care
Heart rate
Hematology
Humans
Male
Medical research
Necrosis
Nitric oxide
Nitric oxide synthase
Nitric Oxide Synthase Type III - genetics
Osteonecrosis - genetics
Pandemics
Pathogenesis
Patients
Polymorphism
Polymorphism, Single Nucleotide
Respiration
Single nucleotide polymorphism
Software
Viral infections
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Summary:Avascular necrosis (AVN) is a debilitating condition characterized by bone tissue death due to inadequate blood supply, leading to joint dysfunction and collapse. This study investigates the potential association between AVN and COVID-19, focusing on genetic factors such as NOS3 polymorphisms. A total of 180 individuals were included, comprising 120 COVID-19 patients and 60 healthy controls. Clinical, haematological, biochemical, and genetic parameters were assessed. Results revealed significant differences in respiratory and heart rates, haematological counts, and biochemical markers between AVN and control groups. Genetic analysis showed a higher prevalence of the TG genotype and G allele in NOS3 rs1799983 polymorphism among AVN patients. Additionally, NOS3 rs2070744 polymorphism correlated with various clinical parameters, including blood pressure, heart rate, and haematological indices. This study highlights the potential role of genetic factors in predisposing individuals to AVN following COVID-19 infection.
ISSN:1755-8794
1755-8794
DOI:10.1186/s12920-024-01928-1