The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention

• Published in: Advances in ophthalmology practice and research 2022-11, Vol.2 (3), p.100063-100063, Article 100063
• Main Authors: Zhang, Yuhang, Qi, Ying, Xie, Xiaohang, Zhang, Fengyan
• Format: Article
• Language: English
• Subjects: Cataract surgery; Diquafosol; Meta-Analysis; Ocular surface
• ISSN: 2667-3762; 2667-3762
• DOI: 10.1016/j.aopr.2022.100063

The effect of interventional time for 3% Diquafosol reatment in post-cataract surgery has not been well established. A meta-analysis was performed to evaluate the improvement of ocular surface condition in post-cataract surgery patients who received 3% DQS for various treatment durations. Studies were performed based on 5 databases: PubMed, Cochrane Library, Web of Science, Embase, and China National Knowledge Infrastructure. Data on changes in Schirmer’s test, tear breakup time (TBUT), corneal staining score, and OSDI score were collected for meta-analysis. A total of 621 affected eyes from 9 independent clinical studies were included. 6 studies conducted Schirmer's test after the application of 3% DQS. Meta-analysis showed that the difference between 3% DQS and control groups was not statistically significant for short-term application (less than or equal to 1 month) (WMD ​= ​0.14, P ​= ​0.27, 95% CI:-0.11∼0.39), but was statistically different for long-term application (longer than or equal to 3 months) (WMD ​= ​0.76, P ​= ​0.03, 95% CI:0.08∼1.45). For the corneal fluorescence staining score, the data from 6 studies indicated that the improvement was statistically significant for short-term application (WMD ​= ​-0.40, P