Wnt/β-catenin signal transduction pathway in prostate cancer and associated drug resistance

Globally, prostate cancer ranks second in cancer burden of the men. It occurs more frequently in black men compared to white or Asian men. Usually, high rates exist for men aged 60 and above. In this review, we focus on the Wnt/β-catenin signal transduction pathway in prostate cancer since many stud...

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Bibliographic Details
Published in:Discover. Oncology 2021-10, Vol.12 (1), p.40-40, Article 40
Main Authors: Wang, Chunyang, Chen, Qi, Xu, Huachao
Format: Article
Language:English
Subjects:
Androgen receptor
Androgens
Cancer Research
Cell division
Cell growth
Cytoplasm
Drug resistance
Genes
Internal Medicine
Kinases
Ligands
Medicine
Medicine & Public Health
Metastasis
Molecular Medicine
Mutation
Oncology
Phosphorylation
Prostate cancer
Proteins
Radiotherapy
Review
Signal transduction
Surgical Oncology
Transcription factors
Tumorigenesis
Wnt/β-catenin pathway
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Summary:Globally, prostate cancer ranks second in cancer burden of the men. It occurs more frequently in black men compared to white or Asian men. Usually, high rates exist for men aged 60 and above. In this review, we focus on the Wnt/β-catenin signal transduction pathway in prostate cancer since many studies have reported that β-catenin can function as an oncogene and is important in Wnt signaling. We also relate its expression to the androgen receptor and MMP-7 protein, both critical to prostate cancer pathogenesis. Some mutations in the androgen receptor also impact the androgen-β-catenin axis and hence, lead to the progression of prostate cancer. We have also reviewed MiRNAs that modulate this pathway in prostate cancer. Finally, we have summarized the impact of Wnt/β-catenin pathway proteins in the drug resistance of prostate cancer as it is a challenging facet of therapy development due to the complexity of signaling pathways interaction and cross-talk.
ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-021-00433-6