Characterization of oral bacterial and fungal microbiome in recovered COVID-19 patients

COVID-19 has emerged as a global pandemic, challenging the world's economic and health systems. Human oral microbiota comprises the second largest microbial community after the gut microbiota and is closely related to respiratory tract infections; however, oral microbiomes of patients who have...

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Bibliographic Details
Published in:BMC microbiology 2023-05, Vol.23 (1), p.123-123, Article 123
Main Authors: Wei, Nana, Zhu, Guangqi, Zhao, Tingxiao, Wang, Yan, Lou, Haifei, Li, Haoxuan, Yang, Zhejuan, Zhang, Zheen, Wang, Qiujing, Han, Mingfang, Lin, Zhibing, Li, Shibo
Format: Article
Language:English
Subjects:
Bacteria
Bacteria - genetics
Care and treatment
Composition
Coronaviruses
COVID-19
Dental care
Dental hygiene
Disease transmission
Fungi
Health care
Humans
Intestinal microflora
Management
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Mouth
Mycobiome
Opportunist infection
Oral bacteria
Oral fungi
Pandemics
Pathogens
Phylogenetics
Recovered patients
Relative abundance
Respiratory tract
Respiratory tract diseases
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Software
Viral diseases
Virus clearance
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Summary:COVID-19 has emerged as a global pandemic, challenging the world's economic and health systems. Human oral microbiota comprises the second largest microbial community after the gut microbiota and is closely related to respiratory tract infections; however, oral microbiomes of patients who have recovered from COVID-19 have not yet been thoroughly studied. Herein, we compared the oral bacterial and fungal microbiota after clearance of SARS-CoV-2 in 23 COVID-19 recovered patients to those of 29 healthy individuals. Our results showed that both bacterial and fungal diversity were nearly normalized in recovered patients. The relative abundance of some specific bacteria and fungi, primarily opportunistic pathogens, decreased in recovered patients (RPs), while the abundance of butyrate-producing organisms increased in these patients. Moreover, these differences were still present for some organisms at 12 months after recovery, indicating the need for long-term monitoring of COVID-19 patients after virus clearance.
ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-023-02872-3