Non-cystic macular thickening on optical coherence tomography as an alternative to fluorescein angiography for predicting retinal vascular leakage in early stages of uveitis

To evaluate the relationship between non-cystic thickening of the macula on optical coherence tomography (OCT) and retinal vascular leakage on fluorescein angiogram (FA) in patients with uveitis. A cross-sectional study of patients seen in the uveitis clinic. Patients with any degree of inflammatory...

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Bibliographic Details
Published in:Scientific reports 2022-08, Vol.12 (1), p.13473-13473, Article 13473
Main Authors: Ebrahimiadib, Nazanin, Kianzad, Zahra, Zarei, Mohammad, Davoudi, Samaneh, Riazi-Esfahani, Hamid, Bazvand, Fatemeh, Mahdizad, Zahra, Modjtahedi, Bobeck S.
Format: Article
Language:English
Subjects:
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Acuity
Angiography
Atrophy
Fluorescein
Humanities and Social Sciences
Inflammation
Leakage
multidisciplinary
Optic nerve
Optics
Retina
Science
Science (multidisciplinary)
Tomography
Uveitis
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Summary:To evaluate the relationship between non-cystic thickening of the macula on optical coherence tomography (OCT) and retinal vascular leakage on fluorescein angiogram (FA) in patients with uveitis. A cross-sectional study of patients seen in the uveitis clinic. Patients with any degree of inflammatory cells in the anterior vitreous were included, provided that no macular cyst or subretinal fluid or macular atrophy was observed in OCT. The correlation between OCT features and best corrected visual acuity (BCVA), the degree of inflammation, and FA findings were examined. The severity of vascular leakage in FA was graded for optic nerve, macula and posterior and peripheral leakage. We used generalized estimation equation to assess the associations between macular thickness and volume with angiographic scores. A total of 43 patients (100 exam data) met inclusion criteria. There was a significant relationship between OCT parameters (central macular thickness, 3 mm and 6 mm perifoveal macular thickness as well as total and central macular volume) with angiographic scores (macular, optic disc, posterior and peripheral vascular leakage score) (all P values
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-17701-2