Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked condition in patients with CKD and end-stage renal disease. It affects ~40% of patients with end-stage renal disease and has been associated with poor quality of life, poor sleep, depression, and mortality. Preval...

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Bibliographic Details
Published in:International journal of nephrology and renovascular disease 2017-01, Vol.10, p.11-26
Main Authors: Shirazian, Shayan, Aina, Olufemi, Park, Youngjun, Chowdhury, Nawsheen, Leger, Kathleen, Hou, Linle, Miyawaki, Nobuyuki, Mathur, Vandana S
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
chronic kidney disease
Chronic kidney failure
Comorbidity
depression
Depression (Mood disorder)
Diagnosis
end stage renal disease
Health aspects
Hemodialysis
Itching
Kidney diseases
Nephrology
Pain
Patients
Pruritus
Quality of life
Review
Skin diseases
Sleep
Studies
Systematic review
uremia
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Summary:Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked condition in patients with CKD and end-stage renal disease. It affects ~40% of patients with end-stage renal disease and has been associated with poor quality of life, poor sleep, depression, and mortality. Prevalence estimates vary based on the instruments used to diagnose CKD-aP, and standardized diagnostic instruments are sorely needed. Treatment studies have often yielded conflicting results. This is likely related to studies that are limited by small sample size, flawed designs, and nonstandardized diagnostic instruments. Several large well-designed treatment trials have recently been completed and may soon influence CKD-aP management.
ISSN:1178-7058
1178-7058
DOI:10.2147/IJNRD.S108045