Long Noncoding RNA LINC00467: Role in Various Human Cancers

Intricate genetic mutations promote the progression of different cancer types. Long noncoding RNAs (lncRNAs) have been widely demonstrated to participate in the genomic activities of various human cancers. Long intergenic non-coding RNA 467 (LINC00467) is an upregulated lncRNA in diverse diseases, e...

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Bibliographic Details
Published in:Frontiers in genetics 2022-06, Vol.13, p.892009-892009
Main Authors: Wu, Di, Li, Rongfei, Liu, Jingyu, Zhou, Changcheng, Jia, Ruipeng
Format: Article
Language:English
Subjects:
biomarker
cancers
Genetics
LINC00467
long noncoding RNAs
microrna sponge
review
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Summary:Intricate genetic mutations promote the progression of different cancer types. Long noncoding RNAs (lncRNAs) have been widely demonstrated to participate in the genomic activities of various human cancers. Long intergenic non-coding RNA 467 (LINC00467) is an upregulated lncRNA in diverse diseases, especially in several types of cancers. Functional experiments of LINC00467 revealed that LINC00467 overexpression enhanced cell chemoresistance, proliferation, migration, and invasion in several types of cancers. Moreover, overexpressed LINC00467 was associated with a poor clinical prognosis. The present evidence suggests that LINC00467 may serve as a promising prognostic indicator and become a novel cancer therapeutic target. In this review, we introduce the biologic functions of lncRNAs and describe the molecular mechanism and clinical significance of LINC00467 in detail.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2022.892009