Secondary Haemophagocytic Lymphohistiocytosis Syndrome (HLH) After Intravesical Instillation of Bacillus Calmette-Guérin (BCG): A Case Report and Review of the Literature

Intravesical bacillus Calmette-Guérin (BCG) instillation is widely used for the treatment of superficial bladder cancer. BCGitis is a serious immune-mediated complication with systematic manifestations and a high mortality rate. Here, we describe a case of a 64-year-old male patient who presented wi...

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Bibliographic Details
Published in:European journal of case reports in internal medicine 2022-10, Vol.9 (10), p.003395-003395
Main Authors: Manganas, Konstantinos, Maria, Angelara, Bountzona, Ioanna, Karamanakos, George, Toskas, Angelos
Format: Article
Language:English
Subjects:
bcgitis
hlh syndrome
intravesical bcg instillation
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Summary:Intravesical bacillus Calmette-Guérin (BCG) instillation is widely used for the treatment of superficial bladder cancer. BCGitis is a serious immune-mediated complication with systematic manifestations and a high mortality rate. Here, we describe a case of a 64-year-old male patient who presented with haemophagocytic lymphohistiocytosis syndrome (HLH) after BCG instillation and was effectively treated with high-dose dexamethasone, intravenous immunoglobulins and anti-tuberculosis treatment.
ISSN:2284-2594
2284-2594
DOI:10.12890/2022_003395