Acute resveratrol exposure does not impact hemodynamics of the fetal sheep

Babies born growth restricted are at an increased risk of both poor short‐and long‐term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratrol (RSV) treatment increases uterine artery blood flow, fetal ox...

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Published in:Physiological reports 2023-06, Vol.11 (12), p.e15749-n/a
Main Authors: Darby, Jack R. T., Williams, Georgia K., Cho, Steven K. S., Meakin, Ashley S., Holman, Stacey L., Quinn, Megan, Wiese, Michael D., Macgowan, Christopher K., Seed, Mike, Morrison, Janna L.
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Blood flow
Blood pressure
cardiovascular
Catheters
Chronic illnesses
Female
Fetal Development
Fetus
Fetuses
FGR
Heart rate
Hemodynamics
Intubation
IUGR
Laboratory animals
Lungs
Magnetic resonance imaging
Medical research
MRI
Nitric oxide
Original
Oxygen
Oxygen consumption
Oxygen saturation
Oxygenation
PC‐MRI
Penicillin
Physiology
Placenta
Polyphenols
Pregnancy
Resveratrol
Resveratrol - pharmacology
Sheep
Surgery
T2 oximetry
Veins & arteries
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cited_by cdi_FETCH-LOGICAL-c5869-49635193cbde252f59c017d84ea4c16ca8b25416d15f79c2db273b1ba5d403be3
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creator Darby, Jack R. T.
Williams, Georgia K.
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Macgowan, Christopher K.
Seed, Mike
Morrison, Janna L.
description Babies born growth restricted are at an increased risk of both poor short‐and long‐term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratrol (RSV) treatment increases uterine artery blood flow, fetal oxygenation, and fetal weight. However, studies suggest that diets high in polyphenols such as RSV may impair fetal hemodynamics. We aimed to characterize the effect of RSV on fetal hemodynamics to further assess its safety as an intervention strategy. Pregnant ewes underwent magnetic resonance imaging (MRI) scans to measure blood flow and oxygenation within the fetal circulation using phase contrast‐MRI and T2 oximetry. Blood flow and oxygenation measures were performed in a basal state and then repeated while the fetus was exposed to RSV. Fetal blood pressure and heart rate were not different between states. RSV did not impact fetal oxygen delivery (DO2) or consumption (VO2). Blood flow and oxygen delivery throughout the major vessels of the fetal circulation were not different between basal and RSV states. As such, acute exposure of the fetus to RSV does not directly impact fetal hemodynamics. This strengthens the rationale for the use of RSV as an intervention strategy against fetal growth restriction.
doi_str_mv 10.14814/phy2.15749
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T. ; Williams, Georgia K. ; Cho, Steven K. S. ; Meakin, Ashley S. ; Holman, Stacey L. ; Quinn, Megan ; Wiese, Michael D. ; Macgowan, Christopher K. ; Seed, Mike ; Morrison, Janna L.</creator><creatorcontrib>Darby, Jack R. T. ; Williams, Georgia K. ; Cho, Steven K. S. ; Meakin, Ashley S. ; Holman, Stacey L. ; Quinn, Megan ; Wiese, Michael D. ; Macgowan, Christopher K. ; Seed, Mike ; Morrison, Janna L.</creatorcontrib><description>Babies born growth restricted are at an increased risk of both poor short‐and long‐term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratrol (RSV) treatment increases uterine artery blood flow, fetal oxygenation, and fetal weight. However, studies suggest that diets high in polyphenols such as RSV may impair fetal hemodynamics. We aimed to characterize the effect of RSV on fetal hemodynamics to further assess its safety as an intervention strategy. Pregnant ewes underwent magnetic resonance imaging (MRI) scans to measure blood flow and oxygenation within the fetal circulation using phase contrast‐MRI and T2 oximetry. Blood flow and oxygenation measures were performed in a basal state and then repeated while the fetus was exposed to RSV. Fetal blood pressure and heart rate were not different between states. RSV did not impact fetal oxygen delivery (DO2) or consumption (VO2). Blood flow and oxygen delivery throughout the major vessels of the fetal circulation were not different between basal and RSV states. As such, acute exposure of the fetus to RSV does not directly impact fetal hemodynamics. 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source Wiley-Blackwell Open Access Collection; Open Access: PubMed Central; Publicly Available Content Database
subjects Animals
Antibiotics
Blood flow
Blood pressure
cardiovascular
Catheters
Chronic illnesses
Female
Fetal Development
Fetus
Fetuses
FGR
Heart rate
Hemodynamics
Intubation
IUGR
Laboratory animals
Lungs
Magnetic resonance imaging
Medical research
MRI
Nitric oxide
Original
Oxygen
Oxygen consumption
Oxygen saturation
Oxygenation
PC‐MRI
Penicillin
Physiology
Placenta
Polyphenols
Pregnancy
Resveratrol
Resveratrol - pharmacology
Sheep
Surgery
T2 oximetry
Veins & arteries
title Acute resveratrol exposure does not impact hemodynamics of the fetal sheep
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