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New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women
Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in n...
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Published in: | BMC medical genetics 2011-04, Vol.12 (1), p.60-60, Article 60 |
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creator | Auguet, Teresa Quintero, Yunuen Riesco, David Morancho, Beatriz Terra, Ximena Crescenti, Anna Broch, Montserrat Aguilar, Carmen Olona, Montserrat Porras, José Antonio Hernandez, Mercè Sabench, Fátima del Castillo, Daniel Richart, Cristóbal |
description | Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in non-diabetic morbidly obese women; and to assess the relationship of vaspin and omentin with anthropometric and metabolic parameters, and other adipo/cytokines.
We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI≥40 kg/m2] and 31 lean [BMI≤25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR.
Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls.
The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women. |
doi_str_mv | 10.1186/1471-2350-12-60 |
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We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI≥40 kg/m2] and 31 lean [BMI≤25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR.
Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls.
The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women.</description><identifier>ISSN: 1471-2350</identifier><identifier>EISSN: 1471-2350</identifier><identifier>DOI: 10.1186/1471-2350-12-60</identifier><identifier>PMID: 21526992</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adipose Tissue - metabolism ; Adult ; Biomarkers - blood ; Case-Control Studies ; circulating levels ; Cytokines - blood ; Cytokines - genetics ; Female ; Gene Expression ; Gene Expression Regulation ; GPI-Linked Proteins - blood ; GPI-Linked Proteins - genetics ; Humans ; Lectins - blood ; Lectins - genetics ; Metabolic Syndrome - blood ; Metabolic Syndrome - genetics ; Middle Aged ; morbid obesity ; mRNA tissue expression ; Obesity, Morbid - blood ; Obesity, Morbid - genetics ; omentin ; Risk Factors ; Serpins - blood ; Serpins - genetics ; vaspin</subject><ispartof>BMC medical genetics, 2011-04, Vol.12 (1), p.60-60, Article 60</ispartof><rights>COPYRIGHT 2011 BioMed Central Ltd.</rights><rights>Copyright ©2011 Auguet et al; licensee BioMed Central Ltd. 2011 Auguet et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b684t-768b34de7b4ea686da5e4bec53c2ff2ef5a61b2d9a6b5e2bf7c75e7e78b74f8b3</citedby><cites>FETCH-LOGICAL-b684t-768b34de7b4ea686da5e4bec53c2ff2ef5a61b2d9a6b5e2bf7c75e7e78b74f8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107780/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107780/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,37012,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21526992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auguet, Teresa</creatorcontrib><creatorcontrib>Quintero, Yunuen</creatorcontrib><creatorcontrib>Riesco, David</creatorcontrib><creatorcontrib>Morancho, Beatriz</creatorcontrib><creatorcontrib>Terra, Ximena</creatorcontrib><creatorcontrib>Crescenti, Anna</creatorcontrib><creatorcontrib>Broch, Montserrat</creatorcontrib><creatorcontrib>Aguilar, Carmen</creatorcontrib><creatorcontrib>Olona, Montserrat</creatorcontrib><creatorcontrib>Porras, José Antonio</creatorcontrib><creatorcontrib>Hernandez, Mercè</creatorcontrib><creatorcontrib>Sabench, Fátima</creatorcontrib><creatorcontrib>del Castillo, Daniel</creatorcontrib><creatorcontrib>Richart, Cristóbal</creatorcontrib><title>New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women</title><title>BMC medical genetics</title><addtitle>BMC Med Genet</addtitle><description>Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in non-diabetic morbidly obese women; and to assess the relationship of vaspin and omentin with anthropometric and metabolic parameters, and other adipo/cytokines.
We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI≥40 kg/m2] and 31 lean [BMI≤25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR.
Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls.
The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women.</description><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>circulating levels</subject><subject>Cytokines - blood</subject><subject>Cytokines - genetics</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation</subject><subject>GPI-Linked Proteins - blood</subject><subject>GPI-Linked Proteins - genetics</subject><subject>Humans</subject><subject>Lectins - blood</subject><subject>Lectins - genetics</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - genetics</subject><subject>Middle Aged</subject><subject>morbid obesity</subject><subject>mRNA tissue expression</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - genetics</subject><subject>omentin</subject><subject>Risk Factors</subject><subject>Serpins - blood</subject><subject>Serpins - genetics</subject><subject>vaspin</subject><issn>1471-2350</issn><issn>1471-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1kktv1DAQgCMEog84c0OWOKAesvUrcXJBKiseK1Ug8ThbtjMOLkm82Mm2_fc43bJqpCIfbM1888kzdpa9InhFSFWeEy5ITlmBc0LzEj_Jjg-Rpw_OR9lJjFcYE1Ex9jw7oqSgZV3T42z6AtdINW7rf7sBItqpuHUDUkODfA_D6IYVWrtgpk6lc4s62EEX7_ItDIDgZhsgRucHNJfNoghodDFOgGzwPep90K7pbpHXkFLXs_ZF9syqLsLL-_00-_nxw4_15_zy66fN-uIy12XFx1yUlWa8AaE5qLIqG1UA12AKZqi1FGyhSqJpU6tSF0C1FUYUIEBUWnCbak-zzd7beHUlt8H1KtxKr5y8C_jQShVGZzqQtSAYDKcWKPASs7omScIZFKrAuKqT693etZ10D41JwwmqW0iXmcH9kq3fSUawEBVOgvd7gXb-P4Jlxvhezk8o5yeUhMpylry9v0XwfyaIo-xdNNB1agA_RVkJXPCaMZLIN3uyVak9N1ifpGam5QUtKow5IzxRq0eotBronfEDWJfii4KzRUFiRrgZWzXFKDffvy3Z8z1rgo8xgD00S1I_6f8-0t7rh0M-8P8-LPsLQY7r-Q</recordid><startdate>20110428</startdate><enddate>20110428</enddate><creator>Auguet, Teresa</creator><creator>Quintero, Yunuen</creator><creator>Riesco, David</creator><creator>Morancho, Beatriz</creator><creator>Terra, Ximena</creator><creator>Crescenti, Anna</creator><creator>Broch, Montserrat</creator><creator>Aguilar, Carmen</creator><creator>Olona, Montserrat</creator><creator>Porras, José Antonio</creator><creator>Hernandez, Mercè</creator><creator>Sabench, Fátima</creator><creator>del Castillo, Daniel</creator><creator>Richart, Cristóbal</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110428</creationdate><title>New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women</title><author>Auguet, Teresa ; Quintero, Yunuen ; Riesco, David ; Morancho, Beatriz ; Terra, Ximena ; Crescenti, Anna ; Broch, Montserrat ; Aguilar, Carmen ; Olona, Montserrat ; Porras, José Antonio ; Hernandez, Mercè ; Sabench, Fátima ; del Castillo, Daniel ; Richart, Cristóbal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b684t-768b34de7b4ea686da5e4bec53c2ff2ef5a61b2d9a6b5e2bf7c75e7e78b74f8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>circulating levels</topic><topic>Cytokines - blood</topic><topic>Cytokines - genetics</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation</topic><topic>GPI-Linked Proteins - blood</topic><topic>GPI-Linked Proteins - genetics</topic><topic>Humans</topic><topic>Lectins - blood</topic><topic>Lectins - genetics</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - genetics</topic><topic>Middle Aged</topic><topic>morbid obesity</topic><topic>mRNA tissue expression</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - genetics</topic><topic>omentin</topic><topic>Risk Factors</topic><topic>Serpins - blood</topic><topic>Serpins - genetics</topic><topic>vaspin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auguet, Teresa</creatorcontrib><creatorcontrib>Quintero, Yunuen</creatorcontrib><creatorcontrib>Riesco, David</creatorcontrib><creatorcontrib>Morancho, Beatriz</creatorcontrib><creatorcontrib>Terra, Ximena</creatorcontrib><creatorcontrib>Crescenti, Anna</creatorcontrib><creatorcontrib>Broch, Montserrat</creatorcontrib><creatorcontrib>Aguilar, Carmen</creatorcontrib><creatorcontrib>Olona, Montserrat</creatorcontrib><creatorcontrib>Porras, José Antonio</creatorcontrib><creatorcontrib>Hernandez, Mercè</creatorcontrib><creatorcontrib>Sabench, Fátima</creatorcontrib><creatorcontrib>del Castillo, Daniel</creatorcontrib><creatorcontrib>Richart, Cristóbal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Science in Context</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auguet, Teresa</au><au>Quintero, Yunuen</au><au>Riesco, David</au><au>Morancho, Beatriz</au><au>Terra, Ximena</au><au>Crescenti, Anna</au><au>Broch, Montserrat</au><au>Aguilar, Carmen</au><au>Olona, Montserrat</au><au>Porras, José Antonio</au><au>Hernandez, Mercè</au><au>Sabench, Fátima</au><au>del Castillo, Daniel</au><au>Richart, Cristóbal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women</atitle><jtitle>BMC medical genetics</jtitle><addtitle>BMC Med Genet</addtitle><date>2011-04-28</date><risdate>2011</risdate><volume>12</volume><issue>1</issue><spage>60</spage><epage>60</epage><pages>60-60</pages><artnum>60</artnum><issn>1471-2350</issn><eissn>1471-2350</eissn><abstract>Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in non-diabetic morbidly obese women; and to assess the relationship of vaspin and omentin with anthropometric and metabolic parameters, and other adipo/cytokines.
We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI≥40 kg/m2] and 31 lean [BMI≤25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR.
Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls.
The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>21526992</pmid><doi>10.1186/1471-2350-12-60</doi><oa>free_for_read</oa></addata></record> |
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subjects | Adipose Tissue - metabolism Adult Biomarkers - blood Case-Control Studies circulating levels Cytokines - blood Cytokines - genetics Female Gene Expression Gene Expression Regulation GPI-Linked Proteins - blood GPI-Linked Proteins - genetics Humans Lectins - blood Lectins - genetics Metabolic Syndrome - blood Metabolic Syndrome - genetics Middle Aged morbid obesity mRNA tissue expression Obesity, Morbid - blood Obesity, Morbid - genetics omentin Risk Factors Serpins - blood Serpins - genetics vaspin |
title | New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women |
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