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New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women

Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in n...

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Published in:BMC medical genetics 2011-04, Vol.12 (1), p.60-60, Article 60
Main Authors: Auguet, Teresa, Quintero, Yunuen, Riesco, David, Morancho, Beatriz, Terra, Ximena, Crescenti, Anna, Broch, Montserrat, Aguilar, Carmen, Olona, Montserrat, Porras, José Antonio, Hernandez, Mercè, Sabench, Fátima, del Castillo, Daniel, Richart, Cristóbal
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creator Auguet, Teresa
Quintero, Yunuen
Riesco, David
Morancho, Beatriz
Terra, Ximena
Crescenti, Anna
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Aguilar, Carmen
Olona, Montserrat
Porras, José Antonio
Hernandez, Mercè
Sabench, Fátima
del Castillo, Daniel
Richart, Cristóbal
description Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in non-diabetic morbidly obese women; and to assess the relationship of vaspin and omentin with anthropometric and metabolic parameters, and other adipo/cytokines. We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI≥40 kg/m2] and 31 lean [BMI≤25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR. Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls. The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women.
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Circulating levels and gene expression in adipose tissue from morbidly obese women</atitle><jtitle>BMC medical genetics</jtitle><addtitle>BMC Med Genet</addtitle><date>2011-04-28</date><risdate>2011</risdate><volume>12</volume><issue>1</issue><spage>60</spage><epage>60</epage><pages>60-60</pages><artnum>60</artnum><issn>1471-2350</issn><eissn>1471-2350</eissn><abstract>Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in non-diabetic morbidly obese women; and to assess the relationship of vaspin and omentin with anthropometric and metabolic parameters, and other adipo/cytokines. We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI≥40 kg/m2] and 31 lean [BMI≤25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR. Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls. The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>21526992</pmid><doi>10.1186/1471-2350-12-60</doi><oa>free_for_read</oa></addata></record>
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subjects Adipose Tissue - metabolism
Adult
Biomarkers - blood
Case-Control Studies
circulating levels
Cytokines - blood
Cytokines - genetics
Female
Gene Expression
Gene Expression Regulation
GPI-Linked Proteins - blood
GPI-Linked Proteins - genetics
Humans
Lectins - blood
Lectins - genetics
Metabolic Syndrome - blood
Metabolic Syndrome - genetics
Middle Aged
morbid obesity
mRNA tissue expression
Obesity, Morbid - blood
Obesity, Morbid - genetics
omentin
Risk Factors
Serpins - blood
Serpins - genetics
vaspin
title New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women
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