TLE4 Is a Critical Mediator of Osteoblast and Runx2-Dependent Bone Development

Healthy bone homeostasis hinges upon a delicate balance and regulation of multiple processes that contribute to bone development and metabolism. While examining hematopoietic regulation by , we have uncovered a previously unappreciated role of on bone calcification using a novel null mouse model. Gi...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2021-08, Vol.9, p.671029-671029
Main Authors: Shin, Thomas H, Theodorou, Evangelos, Holland, Carl, Yamin, Rae'e, Raggio, Cathleen L, Giampietro, Philip F, Sweetser, David A
Format: Article
Language:English
Subjects:
bone calcification
bone mineralization
Cell and Developmental Biology
osteoblast
Runx2
Tle4
Tle4-Runx axis
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Summary:Healthy bone homeostasis hinges upon a delicate balance and regulation of multiple processes that contribute to bone development and metabolism. While examining hematopoietic regulation by , we have uncovered a previously unappreciated role of on bone calcification using a novel null mouse model. Given the significance of osteoblasts in both hematopoiesis and bone development, this study investigated how loss of affects osteoblast function. We used dynamic bone formation parameters and microCT to characterize the adverse effects of loss on bone development. We further demonstrated loss of impacts expression of several key osteoblastogenic genes, including , , and , pointing toward a potential novel mechanism for -dependent regulation of mammalian bone development in collaboration with the RUNX family members.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.671029