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Synthesis and Toxicological Effect of Some New Pyrrole Derivatives as Prospective Insecticidal Agents against the Cotton Leafworm, Spodoptera littoralis (Boisduval)

Herein, a series of biologically active pyrrole derivatives, namely 2-[(3-cyano-5-aryl-1H-pyrrol-2-yl)­thio]­acetic acids 2a-c, 2-[(2-hydroxyethyl)-thio]-5-aryl-1H-pyrrole-3-carbonitriles 3a-c, and 2-[(2-amino-ethyl)­thio]-5-aryl-1H-pyrrole-3-carbonitriles 4a-c, 2,2′-disulfanediylbis­(5-aryl-1H-pyrr...

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Bibliographic Details
Published in:ACS omega 2022-02, Vol.7 (5), p.3990-4000
Main Authors: Abdelhamid, Antar A, Salama, Kaoud S. M, Elsayed, Ahmed M, Gad, Mohamed A, Ali Ali El-Remaily, Mahmoud Abd El Aleem
Format: Article
Language:English
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Summary:Herein, a series of biologically active pyrrole derivatives, namely 2-[(3-cyano-5-aryl-1H-pyrrol-2-yl)­thio]­acetic acids 2a-c, 2-[(2-hydroxyethyl)-thio]-5-aryl-1H-pyrrole-3-carbonitriles 3a-c, and 2-[(2-amino-ethyl)­thio]-5-aryl-1H-pyrrole-3-carbonitriles 4a-c, 2,2′-disulfanediylbis­(5-aryl-1H-pyrrole-3-carbonitriles) 5a-c, 2-((3-cyano-5-aryl-1H-pyrrol-2-yl)­thio)­acetates 6a-c, 2-[(3-cyano-5-phenyl-1H-pyrrol-2-yl)­thio]­acetohydrazides 7a-c, and 2-{2-[(3-cyano-5-aryl-1H-pyrrol-2-yl)­thio]­acetyl}-N-phenyl-hydrazinecarbothioamides 8a-c, as insecticidal agents, were synthesized via adaptable, smoothly accessible 2-(2-oxo-2-arylylethyl)­malononitriles 1a-c. The structures were proved using infrared (IR), nuclear magnetic resonance (NMR), and mass spectrum (MS) techniques. Under laboratory conditions, the toxicological characteristics were tested towards Spodoptera littoralis, cotton leafworm insect type. In respect to the LC50 values, compounds 6a, 7a, 8c, and 3c possess the highest insecticidal bioefficacy, with values of 0.5707, 0.1306, 0.9442, and 5.883 ppm, respectively. The study paves the way towards discovering new materials for potential use as insecticidal active agents.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.1c05049