Metabolic Acidosis, Hyperkalemia, and Renal Unresponsiveness to Aldosterone Syndrome: Response to Treatment with Low-Potassium Diet

Gordon syndrome involves hyperkalemia, acidosis, and severe hypertension (HTN) with hypercalciuria, low renin and aldosterone levels. It is commonly observed in children and adolescents. Such patients respond successfully to sodium restriction and thiazide diuretics. In this article, we present thre...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2020-09, Vol.31 (5), p.1134-1139
Main Authors: Mehandru, Sushil, Haroon, Attiya, Masud, Avais, Shah, Jay, Kaur, Supreet, Masud, Aisha, Hossain, Amir, Asif, Arif, Vachharajani, Tushar
Format: Article
Language:English
Subjects:
Acidosis
Aldosterone
Care and treatment
Diuretics
Glucocorticoids
Hydrochlorothiazide
Hyperkalemia
Hypertension
Metabolism
Potassium
Sodium
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Summary:Gordon syndrome involves hyperkalemia, acidosis, and severe hypertension (HTN) with hypercalciuria, low renin and aldosterone levels. It is commonly observed in children and adolescents. Such patients respond successfully to sodium restriction and thiazide diuretics. In this article, we present three cases of metabolic acidosis, hyperkalemia, and renal unresponsiveness to aldosterone (MeHandRU Syndrome). All three patients did not have HTN or hypercalciuria and demonstrated normal renin and aldosterone levels. These patients did not respond to thiazide-type diuretic therapy and salt restriction. Two males (aged 55- and 62-year) and a female patient (aged 68-year) presented to the clinic with unexplained hyperkalemia (5.9 mEq/L, 5.9 mEq/L and 6.2 mEq/L, respectively). On physical examination, blood pressure (BP) was found to be normal (
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.301183