Mycological Microscopic and Culture Examination of 400 Bronchoalveolar Lavage (BAL) Samples

The frequency of invasive opportunistic mycoses has increased significantly over the past decades especially in immunocompromised patients. Invasive aspergillosis (IA) has become a major cause of morbidity and mortality among these patients. As bronchoalveolar lavage (BAL) fluid samples are generall...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of public health 2012-07, Vol.41 (7), p.70-76
Main Authors: Zarrinfar, H, Saber, S, Kordbacheh, P, Makimura, K, Fata, A, Geramishoar, M, Mirhendi, H
Format: Article
Language:English
Subjects:
Aspergillus
Bronchoalveolar lavage
Cancer
Fungi
Fungus
Infections
Iran
Mortality
Original
Transplants & implants
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 76
container_issue 7
container_start_page 70
container_title Iranian journal of public health
container_volume 41
creator Zarrinfar, H
Saber, S
Kordbacheh, P
Makimura, K
Fata, A
Geramishoar, M
Mirhendi, H
description The frequency of invasive opportunistic mycoses has increased significantly over the past decades especially in immunocompromised patients. Invasive aspergillosis (IA) has become a major cause of morbidity and mortality among these patients. As bronchoalveolar lavage (BAL) fluid samples are generally useful specimens in the diagnosis of invasive pulmonary aspergillosis (IPA), this study was designed to evaluate the incidence of fungal elements in at-risk patients by direct microscopy and culture of BAL samples. In a 16-month period, 400 BAL samples were obtained from several groups of different patients with pulmonary and respiratory disorders and examined by using both direct microscopy and culture. Of the 400 samples, 16 (4%) were positive direct examination with branching septate hyphae and 46 (11.5%) were positive culture: 25 (54%) Aspergillus flavus, 6 (13%) A. fumigatus, 5 (10.9%) A. niger, 1 (2.2%) A. terreus, 3 (6.5%) Penicillium spp. and 6 (13%) mixed A. flavus/A. niger. A. flavus was the most common cause of Aspergillus infection or colonization. Bone marrow transplant (BMT) recipients were the most susceptible group to fungal infection and/or colonization. Among Aspergillus species, A. flavus was the most common isolate in both infections and colonization in Iran. More studies are needed to clarify the epidemiological aspect of aspergillosis in Iran.
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_972526f942274f91862a8d4a33ba8a83</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_972526f942274f91862a8d4a33ba8a83</doaj_id><sourcerecordid>1125244332</sourcerecordid><originalsourceid>FETCH-LOGICAL-d360t-a89aab3bd36126f41c2deb86d67788b499ba57792d0b9b78c5465a157dca72013</originalsourceid><addsrcrecordid>eNpdkU1LHEEQhoegRKP5C6HBix4W-vvjIuiiRljJQT15aKo_du2lZ3rtmVn03zuJRmJOXV318tRbVV-afUoFmUls2M5HrMVe863v1xhzSYX62uxRRgijhO03DzcvvuSySh4yukm-lt6XTfIIuoDmYx7GGtHFM7SpgyGVDpUl4hij81o6_1ggb2PJUNECtrCK6Pj8bHGCbqHd5NgfNrtLyH38_v4eNPeXF3fzn7PFr6vr-dliFpjEwwy0AXDMTT9C5ZITT0N0WgaplNaOG-NAKGVowM44pb3gUgARKnhQFBN20Fy_cUOBtd3U1EJ9sQWS_ZModWWhDsnnaI2iYuphOKWKLw3RkoIOHBhzoEGziXX6xtqMro3Bx26okD9BP1e69GhXZWsZlwYTOgGO3wG1PI2xH2ybeh9zhi6WsbeETA44Z-y39Og_6bqMtZtWZQlm02DcCD6pfvzr6MPK3xuyV32dlwA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1030134954</pqid></control><display><type>article</type><title>Mycological Microscopic and Culture Examination of 400 Bronchoalveolar Lavage (BAL) Samples</title><source>Open Access: PubMed Central</source><creator>Zarrinfar, H ; Saber, S ; Kordbacheh, P ; Makimura, K ; Fata, A ; Geramishoar, M ; Mirhendi, H</creator><creatorcontrib>Zarrinfar, H ; Saber, S ; Kordbacheh, P ; Makimura, K ; Fata, A ; Geramishoar, M ; Mirhendi, H</creatorcontrib><description>The frequency of invasive opportunistic mycoses has increased significantly over the past decades especially in immunocompromised patients. Invasive aspergillosis (IA) has become a major cause of morbidity and mortality among these patients. As bronchoalveolar lavage (BAL) fluid samples are generally useful specimens in the diagnosis of invasive pulmonary aspergillosis (IPA), this study was designed to evaluate the incidence of fungal elements in at-risk patients by direct microscopy and culture of BAL samples. In a 16-month period, 400 BAL samples were obtained from several groups of different patients with pulmonary and respiratory disorders and examined by using both direct microscopy and culture. Of the 400 samples, 16 (4%) were positive direct examination with branching septate hyphae and 46 (11.5%) were positive culture: 25 (54%) Aspergillus flavus, 6 (13%) A. fumigatus, 5 (10.9%) A. niger, 1 (2.2%) A. terreus, 3 (6.5%) Penicillium spp. and 6 (13%) mixed A. flavus/A. niger. A. flavus was the most common cause of Aspergillus infection or colonization. Bone marrow transplant (BMT) recipients were the most susceptible group to fungal infection and/or colonization. Among Aspergillus species, A. flavus was the most common isolate in both infections and colonization in Iran. More studies are needed to clarify the epidemiological aspect of aspergillosis in Iran.</description><identifier>ISSN: 2251-6085</identifier><identifier>EISSN: 2251-6093</identifier><identifier>PMID: 23113213</identifier><language>eng</language><publisher>Iran: Tehran University of Medical Sciences</publisher><subject>Aspergillus ; Bronchoalveolar lavage ; Cancer ; Fungi ; Fungus ; Infections ; Iran ; Mortality ; Original ; Transplants &amp; implants</subject><ispartof>Iranian journal of public health, 2012-07, Vol.41 (7), p.70-76</ispartof><rights>Copyright Dr Ali Akbari Sari, Director of The Commission for Accreditation &amp; Improvement of Iranian Medical Journals Jul 2012</rights><rights>Copyright © Iranian Public Health Association &amp; Tehran University of Medical Sciences 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469012/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469012/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23113213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zarrinfar, H</creatorcontrib><creatorcontrib>Saber, S</creatorcontrib><creatorcontrib>Kordbacheh, P</creatorcontrib><creatorcontrib>Makimura, K</creatorcontrib><creatorcontrib>Fata, A</creatorcontrib><creatorcontrib>Geramishoar, M</creatorcontrib><creatorcontrib>Mirhendi, H</creatorcontrib><title>Mycological Microscopic and Culture Examination of 400 Bronchoalveolar Lavage (BAL) Samples</title><title>Iranian journal of public health</title><addtitle>Iran J Public Health</addtitle><description>The frequency of invasive opportunistic mycoses has increased significantly over the past decades especially in immunocompromised patients. Invasive aspergillosis (IA) has become a major cause of morbidity and mortality among these patients. As bronchoalveolar lavage (BAL) fluid samples are generally useful specimens in the diagnosis of invasive pulmonary aspergillosis (IPA), this study was designed to evaluate the incidence of fungal elements in at-risk patients by direct microscopy and culture of BAL samples. In a 16-month period, 400 BAL samples were obtained from several groups of different patients with pulmonary and respiratory disorders and examined by using both direct microscopy and culture. Of the 400 samples, 16 (4%) were positive direct examination with branching septate hyphae and 46 (11.5%) were positive culture: 25 (54%) Aspergillus flavus, 6 (13%) A. fumigatus, 5 (10.9%) A. niger, 1 (2.2%) A. terreus, 3 (6.5%) Penicillium spp. and 6 (13%) mixed A. flavus/A. niger. A. flavus was the most common cause of Aspergillus infection or colonization. Bone marrow transplant (BMT) recipients were the most susceptible group to fungal infection and/or colonization. Among Aspergillus species, A. flavus was the most common isolate in both infections and colonization in Iran. More studies are needed to clarify the epidemiological aspect of aspergillosis in Iran.</description><subject>Aspergillus</subject><subject>Bronchoalveolar lavage</subject><subject>Cancer</subject><subject>Fungi</subject><subject>Fungus</subject><subject>Infections</subject><subject>Iran</subject><subject>Mortality</subject><subject>Original</subject><subject>Transplants &amp; implants</subject><issn>2251-6085</issn><issn>2251-6093</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpdkU1LHEEQhoegRKP5C6HBix4W-vvjIuiiRljJQT15aKo_du2lZ3rtmVn03zuJRmJOXV318tRbVV-afUoFmUls2M5HrMVe863v1xhzSYX62uxRRgijhO03DzcvvuSySh4yukm-lt6XTfIIuoDmYx7GGtHFM7SpgyGVDpUl4hij81o6_1ggb2PJUNECtrCK6Pj8bHGCbqHd5NgfNrtLyH38_v4eNPeXF3fzn7PFr6vr-dliFpjEwwy0AXDMTT9C5ZITT0N0WgaplNaOG-NAKGVowM44pb3gUgARKnhQFBN20Fy_cUOBtd3U1EJ9sQWS_ZModWWhDsnnaI2iYuphOKWKLw3RkoIOHBhzoEGziXX6xtqMro3Bx26okD9BP1e69GhXZWsZlwYTOgGO3wG1PI2xH2ybeh9zhi6WsbeETA44Z-y39Og_6bqMtZtWZQlm02DcCD6pfvzr6MPK3xuyV32dlwA</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Zarrinfar, H</creator><creator>Saber, S</creator><creator>Kordbacheh, P</creator><creator>Makimura, K</creator><creator>Fata, A</creator><creator>Geramishoar, M</creator><creator>Mirhendi, H</creator><general>Tehran University of Medical Sciences</general><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120701</creationdate><title>Mycological Microscopic and Culture Examination of 400 Bronchoalveolar Lavage (BAL) Samples</title><author>Zarrinfar, H ; Saber, S ; Kordbacheh, P ; Makimura, K ; Fata, A ; Geramishoar, M ; Mirhendi, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d360t-a89aab3bd36126f41c2deb86d67788b499ba57792d0b9b78c5465a157dca72013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aspergillus</topic><topic>Bronchoalveolar lavage</topic><topic>Cancer</topic><topic>Fungi</topic><topic>Fungus</topic><topic>Infections</topic><topic>Iran</topic><topic>Mortality</topic><topic>Original</topic><topic>Transplants &amp; implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zarrinfar, H</creatorcontrib><creatorcontrib>Saber, S</creatorcontrib><creatorcontrib>Kordbacheh, P</creatorcontrib><creatorcontrib>Makimura, K</creatorcontrib><creatorcontrib>Fata, A</creatorcontrib><creatorcontrib>Geramishoar, M</creatorcontrib><creatorcontrib>Mirhendi, H</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Iranian journal of public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarrinfar, H</au><au>Saber, S</au><au>Kordbacheh, P</au><au>Makimura, K</au><au>Fata, A</au><au>Geramishoar, M</au><au>Mirhendi, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycological Microscopic and Culture Examination of 400 Bronchoalveolar Lavage (BAL) Samples</atitle><jtitle>Iranian journal of public health</jtitle><addtitle>Iran J Public Health</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>41</volume><issue>7</issue><spage>70</spage><epage>76</epage><pages>70-76</pages><issn>2251-6085</issn><eissn>2251-6093</eissn><abstract>The frequency of invasive opportunistic mycoses has increased significantly over the past decades especially in immunocompromised patients. Invasive aspergillosis (IA) has become a major cause of morbidity and mortality among these patients. As bronchoalveolar lavage (BAL) fluid samples are generally useful specimens in the diagnosis of invasive pulmonary aspergillosis (IPA), this study was designed to evaluate the incidence of fungal elements in at-risk patients by direct microscopy and culture of BAL samples. In a 16-month period, 400 BAL samples were obtained from several groups of different patients with pulmonary and respiratory disorders and examined by using both direct microscopy and culture. Of the 400 samples, 16 (4%) were positive direct examination with branching septate hyphae and 46 (11.5%) were positive culture: 25 (54%) Aspergillus flavus, 6 (13%) A. fumigatus, 5 (10.9%) A. niger, 1 (2.2%) A. terreus, 3 (6.5%) Penicillium spp. and 6 (13%) mixed A. flavus/A. niger. A. flavus was the most common cause of Aspergillus infection or colonization. Bone marrow transplant (BMT) recipients were the most susceptible group to fungal infection and/or colonization. Among Aspergillus species, A. flavus was the most common isolate in both infections and colonization in Iran. More studies are needed to clarify the epidemiological aspect of aspergillosis in Iran.</abstract><cop>Iran</cop><pub>Tehran University of Medical Sciences</pub><pmid>23113213</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2251-6085
ispartof Iranian journal of public health, 2012-07, Vol.41 (7), p.70-76
issn 2251-6085
2251-6093
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_972526f942274f91862a8d4a33ba8a83
source Open Access: PubMed Central
subjects Aspergillus
Bronchoalveolar lavage
Cancer
Fungi
Fungus
Infections
Iran
Mortality
Original
Transplants & implants
title Mycological Microscopic and Culture Examination of 400 Bronchoalveolar Lavage (BAL) Samples
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T03%3A18%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mycological%20Microscopic%20and%20Culture%20Examination%20of%20400%20Bronchoalveolar%20Lavage%20(BAL)%20Samples&rft.jtitle=Iranian%20journal%20of%20public%20health&rft.au=Zarrinfar,%20H&rft.date=2012-07-01&rft.volume=41&rft.issue=7&rft.spage=70&rft.epage=76&rft.pages=70-76&rft.issn=2251-6085&rft.eissn=2251-6093&rft_id=info:doi/&rft_dat=%3Cproquest_doaj_%3E1125244332%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-d360t-a89aab3bd36126f41c2deb86d67788b499ba57792d0b9b78c5465a157dca72013%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1030134954&rft_id=info:pmid/23113213&rfr_iscdi=true