Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications

The relationship between testosterone and diabetes is an important issue, given the fact that diabetes is becoming a fast-growing epidemic, the morbidity associated with which is more disabling than the disease itself. Various studies have demonstrated the increasing prevalence of hypogonadism in di...

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Published in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2014-01, Vol.7 (default), p.481-486
Main Authors: Beatrice, Anne M, Dutta, Deep, Kumar, Manoj, Kumbenahalli Siddegowda, Shivaprasad, Sinha, Ankur, Ray, Sayantan, Chowdhury, Subhankar
Format: Article
Language:English
Subjects:
Androgens
Body mass index
Cytokines
Diabetes
Fatty acids
Health aspects
Heart attacks
Hormone replacement therapy
Insulin resistance
Meta-analysis
Metabolic syndrome
Mortality
Obesity
Physiological aspects
Review
Testosterone
Tumor necrosis factor-TNF
Type 2 diabetes
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container_end_page 486
container_issue default
container_start_page 481
container_title Diabetes, metabolic syndrome and obesity
container_volume 7
creator Beatrice, Anne M
Dutta, Deep
Kumar, Manoj
Kumbenahalli Siddegowda, Shivaprasad
Sinha, Ankur
Ray, Sayantan
Chowdhury, Subhankar
description The relationship between testosterone and diabetes is an important issue, given the fact that diabetes is becoming a fast-growing epidemic, the morbidity associated with which is more disabling than the disease itself. Various studies have demonstrated the increasing prevalence of hypogonadism in diabetic subjects, but whether this is a cause or effect is still an area of active research. The past couple of decades have witnessed an increasing rate of testosterone prescriptions, even though the relationship between testosterone therapy and cardiovascular effects is still not conclusive. The studies done in this regard have shown conflicting results, and there is still a dearth of long-term, follow-up studies in this field. This paper reviews in brief the postulated mechanisms, observational studies, and interventional data regarding the adverse effects of testosterone therapy in type 2 diabetes mellitus, stressing the cardiovascular risks.
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subjects Androgens
Body mass index
Cytokines
Diabetes
Fatty acids
Health aspects
Heart attacks
Hormone replacement therapy
Insulin resistance
Meta-analysis
Metabolic syndrome
Mortality
Obesity
Physiological aspects
Review
Testosterone
Tumor necrosis factor-TNF
Type 2 diabetes
title Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications
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